{"created":"2023-05-15T14:39:41.932022+00:00","id":54520,"links":{},"metadata":{"_buckets":{"deposit":"9c261ebf-339d-4cdc-8ee1-4b2fd3fb0d9b"},"_deposit":{"created_by":1,"id":"54520","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54520"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054520","sets":["2"]},"author_link":["556831","556832","556838","556835","556830","556836","556833","556834","556839","556837","556829","556840"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"NIRS-M-267","bibliographicPageEnd":"14","bibliographicPageStart":"10","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"第8回技術と安全の報告会報告集"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"顕微鏡下では全く同じように見える受精卵の品質（発生能）を評価することは可能だろうか？世界で初めて体外受精によってヒトが誕生して３５年が経過した。この間に生殖工学技術の普及は目覚ましいが、受精卵の品質は専ら形態的な観察に頼っているのがヒトでもマウスでも現状である。あらかじめ品質が高い受精卵を選別できれば、もっと効率の良い技術支援ができと考えられる。形態に頼らない新たな品質評価法を確立するために、筆者らは受精卵の発生に深く関わる分子メカニズムの１つオートファジーに着目している。オートファジーは細胞質で起こるリソソームを介した大規模な分解経路で、酵母からヒトの細胞までその機能は保存されている。受精卵が発生する過程でもオートファジーは必須であり、実際にオートファジーが働かない受精卵は着床するまでに死んでしまう。本報告書では、個々の受精卵のオートファジーの活性をイメージングする手法とオートファジーの活性を指標にした受精卵の評価法について概説する。","subitem_description_type":"Abstract"}]},"item_10003_relation_10":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"978-4-938987-91-6 ","subitem_relation_type_select":"ISBN"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塚本, 智史"}],"nameIdentifiers":[{"nameIdentifier":"556829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原, 太一"}],"nameIdentifiers":[{"nameIdentifier":"556830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 篤"}],"nameIdentifiers":[{"nameIdentifier":"556831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鬼頭, 靖司"}],"nameIdentifiers":[{"nameIdentifier":"556832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南, 直冶郎"}],"nameIdentifiers":[{"nameIdentifier":"556833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保田, 俊郎"}],"nameIdentifiers":[{"nameIdentifier":"556834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 健"}],"nameIdentifiers":[{"nameIdentifier":"556835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保, 年章"}],"nameIdentifiers":[{"nameIdentifier":"556836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚本 智史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 篤","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鬼頭 靖司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小久保 年章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"556840","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"マウス受精卵の品質評価法の開発～分解の視点からのアプローチ～","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス受精卵の品質評価法の開発～分解の視点からのアプローチ～"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-10"},"publish_date":"2014-12-10","publish_status":"0","recid":"54520","relation_version_is_last":true,"title":["マウス受精卵の品質評価法の開発～分解の視点からのアプローチ～"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:59:55.370227+00:00"}