@inproceedings{oai:repo.qst.go.jp:00054482,
 author = {Saito, Shigeyoshi and Hasegawa, Sumitaka and Furukawa, Takako and Saga, Tsuneo and Aoki, Ichio and 齋藤 茂芳 and 長谷川 純崇 and 古川 高子 and 佐賀 恒夫 and 青木 伊知男},
 book = {Proc. Intl. Soc. Mag. Reson. Med.},
 month = {May},
 note = {Recent studies on the utility of manganese have shown that manganese-enhanced MRI (MEMRI) can detect cellular alterations in tumor models [1][2]. In addition, the intercellular contrast agent MnCl2 has been successfully used to assess cell viability in heart ischemia [3], and cells can be easily labeled using Mn2+ in vitro [4]. Hasegawa et al. reported that MEMRI can reflect MnSOD over-expression in a tumor model [2]. Radiotherapy using high-energy x-rays treats malignancies with the intention of destroying or inactivating cells while preserving normal tissue integrity. We investigated the relationship between x-ray irradiation and Mn uptake in tumor cells and tested whether MEMRI can detect radiation-induced cell disturbances at an early stage both in vitro and in vivo.},
 title = {In-Vivo Detection of Cell Cycle Arrest Using Manganese-Enhanced MRI (MEMRI)},
 volume = {19},
 year = {2011}
}