@inproceedings{oai:repo.qst.go.jp:00054473,
 author = {Kokuryo, Daisuke and Yasutaka, Anraku and Akihiro, Kishimura and Sayaka, Tanaka and Kano, Mitsunobu and Nobuhiro, Nishiyama and Saga, Tsuneo and Aoki, Ichio and Kazunori, Kataoka and 國領 大介 and 狩野  光伸 and 佐賀 恒夫 and 青木 伊知男},
 book = {Proc. Intl. Soc. Mag. Reson. Med.},
 month = {Apr},
 note = {The detection of early-stage tumors, especially in the metastatic case, is important for improving treatment efficacy and prolonging patient survival. Super paramagnetic iron-oxide (SPIO) nanoparticles are a highly sensitive MRI contrast agent and have the potential to be a powerful tool for a wide range of clinical and pre-clinical cancer studies.1 However, after intravenous administration conventional SPIO nanoparticles (eg ferucarbotran) in the bloodstream are rapidly captured by the reticuloendothelial system (RES), predominantly in the liver. Therefore, to avoid recognition by the RES and effectively target tumour tissue, it is necessary to equip the SPIO nanoparticles with a "stealth" capability. Previously, it has been reported that polyion complex vesicles (Nano-PICsomes), which are composed of biocompatible poly(ethylene glycol) (PEG) and poly(amino acid)s, can be easily engineered for size and are capable of prolonged circulation in the bloodstream.2, 3 In this paper, a novel MR and fluorescence contrast nanocarrier (named "SPIO-Cy5-PICsome"), that is specific for targeted tumor imaging and is based on the encapsulation of FDA-approved SPIO nanoparticles inside Nano-PICsomes, was synthesized and evaluated in vitro and in vivo for its ability to detect small tumors with high-field MRI.},
 pages = {1869--1869},
 title = {SPIO-Loaded Unilamellar Polyion Complex Vesicles (SPIO-Cy5-PICsomes) as a High Relaxivity Contrast Agent for Tumor Detection},
 volume = {21},
 year = {2013}
}