@inproceedings{oai:repo.qst.go.jp:00054262,
 author = {Imada, Hiroshi and Yasuda, Shigeo and Yamada, Shigeru and Shinoto, Makoto and Oonishi, Kazuhiko and Kamada, Tadashi and Tsujii, Hirohiko and 今田 浩史 and 安田 茂雄 and 山田 滋 and 篠藤 誠 and 大西 和彦 and 鎌田 正 and 辻井 博彦},
 book = {Proceedings of Japanease-European Joint Symposium on Ion Cancer Therapy and NIRS-KI Joint Symposium on Ion-Radiation Sciences, September 9 & 10-11, 2010 Karolinska University Hospital, Solna Stockholm, Sweden Organized by National Institute of Radiological Sciences, Japan and Karolinska Institute, Sweden},
 issue = {235},
 month = {},
 note = {The objective of this paper is to present a summary of a clinical study on carbon ion radiotherapy (C-ion RT) for hepatocellular carcinoma (HCC) conducted from April 1995 to August 2005 at the Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, in Japan. A total of 193 patients with HCC were enrolled in the clinical trial of carbon ion beams. In the first and second phase I/II clinical trials, dose escalation experiments were carried out in incremental steps of 10%, resulting in the confirmation of both the safety and efficacy of short-course regimens of 12, 8 and 4 fractions. Based on the results, a phase II clinical study with fixed fractionation, that is, 52.8 GyE/4 fractions, was performed. A total of 47 patients were treated during this phase II study, which resulted in low toxicity and attained a high local control rate (96%) for 5 years after treatment. The last clinical study was conducted from April 2003 to August 2005 with a more hypofractionated regimen of 2 fractions/2 days, in which 36 patients were safely treated within a dose escalation range from 32.0 GyE to 38.8 GyE. The 2-fraction therapy protocol is continuing under the license of Highly Advanced Medical Technology. There have been no therapy-related deaths and no severe adverse events. We can conclude that, because of the low toxicity and high local control rate, C-ion RT has a promising potential as a new, radical, and minimally invasive therapeutic option for HCC.},
 pages = {36--43},
 publisher = {National Institute of Radiological Sciences},
 title = {Carbon Ion Radiotherapy for Liver Cancer},
 volume = {NIRS-M},
 year = {2010}
}