{"created":"2023-05-15T14:39:21.701531+00:00","id":54064,"links":{},"metadata":{"_buckets":{"deposit":"138e0b4c-9d66-429d-a95f-55603e06d85e"},"_deposit":{"created_by":1,"id":"54064","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54064"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054064","sets":["2"]},"author_link":["551888","551885","551892","551889","551890","551894","551884","551897","551893","551886","551896","551887","551891","551895"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"0506","bibliographicVolumeNumber":"2008","bibliographic_titles":[{"bibliographic_title":"World Molecular Imaging Congress"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Logan graphical analysis (LGA) is a widely used algorithm for PET quantitative\nimaging. In LGA, a total distribution volume (VT) is derived as a slope in the linear relation between both radiopharmaceutical concentrations in tissues and arterial plasma after the time, t*, when the radiopharmaceutical distributes uniformly in regional tissues, and therefore t* should be specified automatically for every voxels. This study proposes a new algorithm for t* determination, ratLGA, based on the runs test, which is a nonparametric hypothesis test for randomness. In ratLGA, LGA was applied to compute residuals for the line estimation with a set of feasible t* for PET studies. Then, the runs test was employed to decide the randomness of signs in the residuals with a significance level of 0.05. ratLGA is expected to be robust against the noise observed in voxel-based tTACs. Using t* (5 to 80 [min]), ratLGA was applied to the simulated and clinical data for 11C-SA4503, which is a ligand for the sigma1 receptors (Sakata, NeuroImage, 2007). In the simulation, VT was widely ranged from 10 to 60 [mL/cm3] considering the kinetics of SA4503, and the linear regressions for estimated VT were y=0.94x-1.23 in ratLGA and\ny=0.81x+3.80 when t* was fixed at 30 [min] (Sakata, 2007). The underestimation was improved by ratLGA. ratLGA increased a contrast in clinical VT images as shown in figures. Figures A and B were VT in case of ratLGA and the fixed t*, respectively, and Figure C showed the difference. In conclusion, the runs test is promising to determine t* for LGA.","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"551884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogaki, Hiroto"}],"nameIdentifiers":[{"nameIdentifier":"551885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"551886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shidahara, Miho"}],"nameIdentifiers":[{"nameIdentifier":"551887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"551888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"551889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Mikio"}],"nameIdentifiers":[{"nameIdentifier":"551890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大柿 宏人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551893","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551894","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田 宗之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551895","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石渡 喜一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551896","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅 幹生","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"551897","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Determination of Starting Time in Logan Graphical Analysis Using the Runs Test for Quantitative PET Imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Determination of Starting Time in Logan Graphical Analysis Using the Runs Test for Quantitative PET Imaging"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-24"},"publish_date":"2008-10-24","publish_status":"0","recid":"54064","relation_version_is_last":true,"title":["Determination of Starting Time in Logan Graphical Analysis Using the Runs Test for Quantitative PET Imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:05:18.148428+00:00"}