{"created":"2023-05-15T14:39:16.324479+00:00","id":53942,"links":{},"metadata":{"_buckets":{"deposit":"51938acb-a3c7-48de-90e2-efd6b67b1093"},"_deposit":{"created_by":1,"id":"53942","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"53942"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00053942","sets":["2"]},"author_link":["550447","550446","550452","550445","550455","550449","550448","550450","550451","550454","550453","550456"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"58","bibliographicPageStart":"49","bibliographicVolumeNumber":"NIRS-M-194","bibliographic_titles":[{"bibliographic_title":"NIRS-CNAO Joint Symposium on Carbon Ion Radiotherapy"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"From 1994 to 1999, we conducted a phase I/II clinical trial for stage I non-small cell lung cancer (NSCLC) by using carbon ion beams alone, demonstrating optimal doses of 90 GyE in 18 fractions over 6 weeks and 72 GyE in 9 fractions over 3 weeks for achieving more than 95% local control with minimal pulmonary damage. In the present study, the total dose was fixed at 72 GyE in 9 fractions over 3 weeks, and at 52.8 GyE for stage IA and 60 GyE for stage 1B in 4 fractions over 1 week. Following this schedule, we conducted a phase II clinical trial for stage I NSCLC from 1999 to 2003. Most targets were irradiated from four oblique directions. A respiratory-gated irradiation system was used for all sessions. Local control and survival were assessed by the Kaplan-Meier method. For statistical testing, the long-rank test was used.\nThe local control rate for all patients was 91.5%, and those for T1 and T2 tumors were 96.3% and 84.7%, respectively. While there was significant difference (p=0.0156) in tumor control rate between T1 and T2, there was no significant difference (P=0.1516) between squamous and non-squamous. The five-year cause-specific survival rate was 67.0% (IA: 84.4, IB: 43.7), and overall survival was 45.3% (IA: 53.9, 1B: 34.2). No adverse effects greater than grade 3 occurred in the lung. Carbon beam radiotherapy, an excellent new modality in terms of high QOL and ADL, was proven to be a valid alternative to surgery for stage I cancer, especially for elderly and inoperable patients.","subitem_description_type":"Abstract"}]},"item_10003_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"National Institute of Radiological Sciences"}]},"item_10003_relation_10":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"4-9389-8737","subitem_relation_type_select":"ISBN"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyamoto, Tadaaki"}],"nameIdentifiers":[{"nameIdentifier":"550445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Baba, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"550446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yashiro, Tomoyasu"}],"nameIdentifiers":[{"nameIdentifier":"550447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugane, Toshio"}],"nameIdentifiers":[{"nameIdentifier":"550448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Mio"}],"nameIdentifiers":[{"nameIdentifier":"550449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"550450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本 忠昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場 雅行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢代 智康","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須金 紀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中嶋 美緒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550456","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Carbon Ion Radiotherapy in Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Radiotherapy in Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-04-28"},"publish_date":"2008-04-28","publish_status":"0","recid":"53942","relation_version_is_last":true,"title":["Carbon Ion Radiotherapy in Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:06:43.239935+00:00"}