{"created":"2023-05-15T14:39:13.446231+00:00","id":53880,"links":{},"metadata":{"_buckets":{"deposit":"02e70d0b-7fb9-4e63-a318-85ae3bc8bdcd"},"_deposit":{"created_by":1,"id":"53880","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"53880"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00053880","sets":["2"]},"author_link":["549804","549802","549800","549798","549799","549805","549807","549803","549796","549797","549808","549801","549809","549806"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"15","bibliographicPageStart":"11","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"乳癌基礎研究"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"がんは、正常細胞に比べアミノ酸の取り込みのバランスが崩れており、取り込みを支えるトランスポーターの発現プロファイルが異なっている。本研究では、種々の因子（ガンマ線、炭素線，MNU、PhIP）により誘発したラット乳がんにおいて、アミノ酸のトランスポーターの発現と遺伝子のプロモーター領域のメチル化の検討を行った。その結果、発がん因子にかかわらず大きなアミノ酸のトランスポーターであるSlc7a5、Slc7a1は高発現し、Slc1a5やSlc7a10、Slc36a2などの小さな中性アミノ酸のトランスポーターは顕著な発現低下を示した。Slc7a10は、プロモーターにCpGアイランドをもつため、メチル化を検討したところ、MNUやPhIPで誘発した乳がんではSlc7a10の高度なメチル化が確認できたが、炭素線で誘発したがんではメチル化の程度が低かった。すなわち、メチル化は発がん物質に依存していることが示唆された。","subitem_description_type":"Abstract"}]},"item_10003_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1343-2028","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"549796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡, 達彦"}],"nameIdentifiers":[{"nameIdentifier":"549797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"549798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大町, 康"}],"nameIdentifiers":[{"nameIdentifier":"549799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口, 悠"}],"nameIdentifiers":[{"nameIdentifier":"549800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下, 聡"}],"nameIdentifiers":[{"nameIdentifier":"549801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"牛島, 俊和"}],"nameIdentifiers":[{"nameIdentifier":"549802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"549803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大町 康","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口 悠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"549809","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"ラット乳癌における膜型トランスポーターの発現とメチル化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラット乳癌における膜型トランスポーターの発現とメチル化"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-08-07"},"publish_date":"2007-08-07","publish_status":"0","recid":"53880","relation_version_is_last":true,"title":["ラット乳癌における膜型トランスポーターの発現とメチル化"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:07:28.310731+00:00"}