@inproceedings{oai:repo.qst.go.jp:00053817, author = {Obata, Takayuki and Tomiyasu, Moyoko and Kashikura, Kenichi and Hirano, Yoshiyuki and Nonaka, Hiroi and Ikehira, Hiroo and et.al and 小畠 隆行 and 富安 もよこ and 柏倉 健一 and 平野 好幸 and 野中 博意 and 池平 博夫}, book = {Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition}, month = {May}, note = {Darquie et al. reported a new fMRI method using apparent diffusion coefficient (ADC) showing a different transient feature from other fMRI methods at visual cortex activation, which had a slow return to baseline after stimulation [1]. They suggested that the ADC change may reflect cortical cell swelling due to neuron activation. However, further study to confirm this hypothesis has not been performed. The timing of the slow return to baseline in the ADC time course is mostly consistent with undershoot in the blood-oxygen-level-dependent (BOLD) response, suggesting a relationship between the slow return in ADC and undershoot in BOLD transients. Therefore, we analyzed post-stimulus undershoot in heavily diffusion-weighted MRI (DWI) (b=1400 s/mm2), and compared it with those in weakly DWI (b=200 s/mm2) and BOLD image. The 1400 s/mm2 and 200 s/mm2 values of b-factor are the same as those used for calculation of ADC in the above report [1].}, title = {Minimization of Post-Stimulus Undershoot in Heavily Diffusion-Weighted Functional Magnetic Resonance Imaging}, volume = {14}, year = {2006} }