{"created":"2023-05-15T14:39:06.763719+00:00","id":53729,"links":{},"metadata":{"_buckets":{"deposit":"5dcfad67-7c6a-487a-b198-04f773153965"},"_deposit":{"created_by":1,"id":"53729","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"53729"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00053729","sets":["2"]},"author_link":["548339","548348","548351","548345","548349","548346","548343","548342","548350","548344","548340","548347","548341"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"44","bibliographicPageStart":"41","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Proceedings of the Japan-France Workshop on Radiobiology and Isotopic Imaging"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"RNA polymerase II (pol II) is a multi-subunit enzyme responsible for the transcription of most genes in eukaryotes. If forms enormous complexes, or holoenzymes, that associates with other proteins involved in related functions like splicing, polyadenylation, and the repair of damage in DNA. In turn, several such holoenzymes are organized into even larger structures called transcription factories (Cook, 1999). At the heart of each individual polymerizing complex lies the catalytic subunit, RPB1 this is the largest subunit found in the core enzyme.\n Sister chromatid exchange (SCE) is as an indicator of mutagenicity and carcinogenicity. A temperature-sensitive (ts) mutant of the CHO-K1 line, tsTM4, exhibited abnormal induction of SCEs along with a decrease of DNA synthesis in the cells arrested in S phase at the non-permissive temperature. These ts defects of tsTM4 were complemented by the human genomic fragments containing the entire coding region of RPB1 gene, as well as green fluorescent protein (GFP) tagged human rpb1 cDNA.","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sugaya, Kimihiko"}],"nameIdentifiers":[{"nameIdentifier":"548339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasanuma, Shunichi"}],"nameIdentifiers":[{"nameIdentifier":"548340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ajimura, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"548341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hideo"}],"nameIdentifiers":[{"nameIdentifier":"548342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morimyo, Mitsuoki"}],"nameIdentifiers":[{"nameIdentifier":"548343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cook, Peter"}],"nameIdentifiers":[{"nameIdentifier":"548344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mita, Kazuei"}],"nameIdentifiers":[{"nameIdentifier":"548345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅谷 公彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"548346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笹沼 俊一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"548347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"味村 正博","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"548348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 秀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"548349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森明 充興","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"548350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三田 和英","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"548351","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Genome stability and transcription by RNA polymerase II : Temperature-sensitive mutants of the largest subunit of pol II showing genome instability","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genome stability and transcription by RNA polymerase II : Temperature-sensitive mutants of the largest subunit of pol II showing genome instability"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-16"},"publish_date":"2006-06-16","publish_status":"0","recid":"53729","relation_version_is_last":true,"title":["Genome stability and transcription by RNA polymerase II : Temperature-sensitive mutants of the largest subunit of pol II showing genome instability"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:09:17.832823+00:00"}