@inproceedings{oai:repo.qst.go.jp:00053497, author = {Nojima, Kumie and Nakadai, Taeko and Kouno, Yukio and E., Vazquez Marcelo and Yasuda, Nakahiro and Nagaoka, Shunji and 野島 久美恵 and 中台 妙子 and 河野 幸雄 and 安田 仲宏 and 長岡 俊治}, book = {Biological Sciences in Space}, month = {Nov}, note = {To investigate effects of low dose heavy particle radiation to CNS system , we adopted mouse neonatal brain cells in culture being exposed to heavy ion by HIMAC at NIRS and NSRL at BNL. The applied dose varied from 0,05 Gy up to 2.0 Gy. The subsequent biological effects were evaluated by an induction of apoptosis and neuron survival focusing on the dependencies of the animal strains, SCID, B6, BC3F1, C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to particle radiation as evaluated by 10% apoptotic criterion. The LET dependency was compared with using SCID and B6 cells exposing to different ions (H, C, Ne, Si, Ar, and Fe). Although no detectable LET dependency was observed in the high LET (55~200KeV/mm) and low dose (<0.5 Gy) reasions. The survivability profiles of the neurons were different in the mouse strains and ions.}, pages = {114--115}, title = {Effects of Heavy Ion to the Primary Culture of Mouse Brain Cells}, volume = {18}, year = {2004} }