@inproceedings{oai:repo.qst.go.jp:00053261,
 author = {Yoshida, Kazuko and Hirabayashi, Yoko and Sado, Toshihiko and Inoue, Tohoru and 吉田 和子 and 平林 容子 and 佐渡 敏彦 and 井上 達},
 book = {Radiation and Homeostasis : Proceedings of the International Symposium of Radiation and Homeostasis, held in Kyoto, Japan, 13-16 July 2001(International Congress Series ; no. 1236)},
 month = {},
 note = {Dietary restriction, especially caloric restriction (CR), is a major carcinogenic modifier during experimental carcinogenesis. We attempted to examine the effects of CR on radiation-induced myeloid leukemia (MyL). The spontaneous incidence of MyL in C3H/He mice is 1.1%, and the incidence increases to 21.6% by X-ray irradiation. However, the incidence was decreased in the CR groups; it was 7.9% in RA (life-span restricted diet from the age of 6 weeks), 10.7% in RB (restricted diet after irradiation), 16.2% in RC (restricted from 6weeks old until irradiation at 10 weeks old). The differences between both the RA and RB groups and the non-restricted group were statistically significant. The significantly fewer hematopoietic stem cells (HSC), potential target cells for radiation leukemia in the RA and RC at the time of radiation exposure, and the smaller cycling fraction of HSC under CR in the femur of restricted mice (26+-4.5%) than in the non-restricted group (44+-20%), were responsible for this underlying mechanism. CR contributes to the incidence reduction of leukemia at the initiation stage of leukemogenesis and, more significantly, to the reduction of MyL during the promotion stage of radiation leukemogenesis.},
 pages = {455--458},
 publisher = {Elsevier},
 title = {Nutrition status and radiation-induced cancer in mice},
 year = {2002}
}