{"created":"2023-05-15T14:38:42.117657+00:00","id":53235,"links":{},"metadata":{"_buckets":{"deposit":"d35a31e1-0e5f-4b0c-b728-9057c8390ab7"},"_deposit":{"created_by":1,"id":"53235","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"53235"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00053235","sets":["2"]},"author_link":["543324","543323","543326","543320","543318","543321","543327","543317","543325","543328","543322","543319"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"194","bibliographicPageStart":"191","bibliographic_titles":[{"bibliographic_title":"Molecular Mechanisms for Radiation-Induced Cellular Response and Cancer Development : Proceeding of the International Symposium on Biological Effects of Low Dose Radiation"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In the past 5 years, a series of study was done at our institute to\ninvestigate radiation effects on the embryogenesis in mice with an emphasis\non mechanisms involved in the radiation-induced adaptive response and the\nrole of radiation-induced apoptosis played in teratogenesis in the late\nperiod of organogenesis. Using the limb bud system, we first found that\nradiation-induced apoptosis is involved in malformations, namely,\nradiation-induced apoptosis in the predigital regions of embryonic limb buds\nis responsible for digital defects in ICR mice. Examination of embryonic\nC57BL/6J mice with different p53 status led to further finding that\nsusceptibility to the radiation-induced apoptosis and digital defects\ndepends on both the p53 status and the radiation dose. p53 wild-type mice\nappeared to be the most sensitive, while p53 knockout mice were the most\nresistant. These results indicate that p53-dependent apoptosis mediates\nradiation-induced digital defects. The existence of a radioadaptive response\nin fetuses, i.e., the priming dose significantly decreases the apoptosis\ninduction, prenatal death, and digital defects in the living fetuses induced\nby the challenging dose, was found first in ICR strain mice and later\nconfirmed again in C57BL/6J mice. p53 heterozygous embryos did not show the\nradioadaptive response, indicating the involvement of p53 in the\nradioadaptive response.","subitem_description_type":"Abstract"}]},"item_10003_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Institute for Environmental Science"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"543317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyama, Harumi"}],"nameIdentifiers":[{"nameIdentifier":"543318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nose, Masako"}],"nameIdentifiers":[{"nameIdentifier":"543319","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukawa, Osami"}],"nameIdentifiers":[{"nameIdentifier":"543320","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"543321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayata, Isamu"}],"nameIdentifiers":[{"nameIdentifier":"543322","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"543323","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山 ハルミ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"543324","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"能勢 正子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"543325","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"湯川 修身","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"543326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 武","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"543327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"早田 勇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"543328","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Radioactive Response and radiation-Induced Teratogenesis in the Late Period of Organogenesis in Mice: Involvement of p53-Dependent Apoptosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radioactive Response and radiation-Induced Teratogenesis in the Late Period of Organogenesis in Mice: Involvement of p53-Dependent Apoptosis"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-11-14"},"publish_date":"2003-11-14","publish_status":"0","recid":"53235","relation_version_is_last":true,"title":["Radioactive Response and radiation-Induced Teratogenesis in the Late Period of Organogenesis in Mice: Involvement of p53-Dependent Apoptosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:14:56.323156+00:00"}