{"created":"2023-05-15T14:38:25.456402+00:00","id":49593,"links":{},"metadata":{"_buckets":{"deposit":"3c65279b-83ea-4b90-8aaa-c6831cab68a1"},"_deposit":{"created_by":1,"id":"49593","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49593"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049593","sets":["1"]},"author_link":["500994","500996","500991","500992","500993","500995"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"264","bibliographicPageStart":"255","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"放射線生物研究（Radiation Biology Research Communications）"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線ホルミシスは放射線に対する生物の適応応答の一種で、高線量では生体に有害な電離放射線が低線量ではSOD やDNA 修復系を活性化させることにより有益な効果を有するという現象である。モデル生物線虫においてもその誘導メカニズムについて、抗酸化およびミトコンドリアのエネルギー代謝系の関与などさまざまな解析結果の集積がある。線虫C. elegans を用いた照射実験でも線質として低LET 放射線がほとんどで、放射線由来のフリーラジカルによる酸化ストレスに対するホルミシス効果として老化の表現型に注目した報告が多い。これは、寿命解析に適したモデル生物としての所以である。ここでは、主に放射線ホルミシスによる寿命延長メカニズムについてこれまでの報告を概説するとともに、エネルギー代謝のエピジェネティクスによる制御など我々の未発表データを含む最新の知見を紹介する。また、高等動物における放射線ホルミシスとの差異や共通点についても改めて考える機会としたい。","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"放射線生物研究会"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0441-747X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"簗瀬, 澄乃（大東文化大学）"}],"nameIdentifiers":[{"nameIdentifier":"500991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 芳代"}],"nameIdentifiers":[{"nameIdentifier":"500992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"秋山（張）, 秋梅（京都大学）"}],"nameIdentifiers":[{"nameIdentifier":"500993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂下, 哲哉"}],"nameIdentifiers":[{"nameIdentifier":"500994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 芳代","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"500995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂下 哲哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"500996","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"モデル生物線虫における放射線ホルミシスと新たな知見","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"モデル生物線虫における放射線ホルミシスと新たな知見"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-12"},"publish_date":"2019-02-12","publish_status":"0","recid":"49593","relation_version_is_last":true,"title":["モデル生物線虫における放射線ホルミシスと新たな知見"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:19:07.130644+00:00"}