{"created":"2023-05-15T14:38:24.459798+00:00","id":49574,"links":{},"metadata":{"_buckets":{"deposit":"c96a207e-6f75-4788-b40e-cb78b20be526"},"_deposit":{"created_by":1,"id":"49574","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49574"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049574","sets":["1"]},"author_link":["776644","776646","776640","776647","776641","776648","776642","776645","776643"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1134","bibliographicPageStart":"1124","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"International journal of oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Osteosarcoma (OS) is a malignant tumor of the bone derived from primitive transformed cells of the mesenchymal origin. Local low-linear energy transfer (LET) radiotherapy has limited benefits on OS owing to its radioresistance. Thus, this study aimed to investigate the effects of high-LET radiation on human OS. Therefore, the human OS cell lines, U2O2 and KHOS/NP, were examined in vitro, or an orthotopic mouse xenograft model was studied in vivo after treatment with low-LET (gamma-ray) and high-LET (neutron) radiation. Notably, OS cells were significantly more sensitive to high-LET radiation in vitro and in the orthotopic xenograft tumor model. Specifically, neutron radiation treatment increased the relative percentage of apoptotic sub-G1 phase cells via caspase-3/9 activation; increased intracellular reactive oxygen species, autophagy, and DNA damage; and decreased invasion and migration. Similarly, the mean size of gamma-irradiated (8 Gy) orthotopic KHOS/NP OS was 195 mm3 at 6 weeks after gamma-irradiation (8 Gy), but it was only 150 mm3 in mice treated with high-LET neutron radiotherapy. Significantly, our results provide a rationale for the use of high-LET radiotherapy to treat patients with OS.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"D.A. Spandidos"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28849129","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3892/ijo.2017.4102","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1019-6439","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ho Kim, Eun"}],"nameIdentifiers":[{"nameIdentifier":"776640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mi-Sook, Kim"}],"nameIdentifiers":[{"nameIdentifier":"776641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kyung-Hee, Lee"}],"nameIdentifiers":[{"nameIdentifier":"776642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei"}],"nameIdentifiers":[{"nameIdentifier":"776643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kyoung Jeong, Youn"}],"nameIdentifiers":[{"nameIdentifier":"776644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jae-Soo, Koh"}],"nameIdentifiers":[{"nameIdentifier":"776645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chang-Bae, Kong"}],"nameIdentifiers":[{"nameIdentifier":"776646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ho Kim, Eun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"776647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Sei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"776648","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of low- and high-linear energy transfer radiation on in vitro and orthotopic in vivo models of osteosarcoma by activation of caspase-3 and -9.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of low- and high-linear energy transfer radiation on in vitro and orthotopic in vivo models of osteosarcoma by activation of caspase-3 and -9."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-07"},"publish_date":"2019-02-07","publish_status":"0","recid":"49574","relation_version_is_last":true,"title":["Effect of low- and high-linear energy transfer radiation on in vitro and orthotopic in vivo models of osteosarcoma by activation of caspase-3 and -9."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:19:46.385711+00:00"}