{"created":"2023-05-15T14:38:19.932550+00:00","id":49468,"links":{},"metadata":{"_buckets":{"deposit":"a0e92007-fc49-4d09-a3e4-ef6bbbe0e30c"},"_deposit":{"created_by":1,"id":"49468","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49468"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049468","sets":["1"]},"author_link":["499608","499606","499604","499607","499602","499610","499609","499612","499600","499605","499601","499603","499613","499611"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Molecular Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To explore suitable imaging probes for early and specific detection of pancreatic cancer, we demonstrated that a6b4 integrin is a\ngood target and employed single-photon emission computed tomography (SPECT) or near-infrared (NIR) imaging for immunotargeting.\nExpression levels of a6b4 were examined by Western blotting and flow cytometry in certain human pancreatic cancer\ncell lines. The human cell line BxPC-3 was used for a6b4-positive and a mouse cell line, A4, was used for negative counterpart. We\nlabeled antibody against a6b4 with Indium-111 (111In) or indocyanine green (ICG). After injection of 111In-labeled probe to tumorbearing\nmice, biodistribution, SPECT, autoradiography (ARG), and immunohistochemical (IHC) studies were conducted. After\nadministration of ICG-labeled probe, in vivo and ex vivo NIR imaging and fluorescence microscopy of tumors were performed.\nBxPC-3 tumor showed a higher radioligand binding in SPECT and higher fluorescence intensity as well as a delay in the probe\nwashout in NIR imaging when compared to A4 tumor. The biodistribution profile of 111In-labeled probe, ARG, and IHC confirmed\nthe a6b4 specific binding of the probe. Here, we propose that a6b4 is a desirable target for the diagnosis of pancreatic cancer and\nthat it could be detected by radionuclide imaging and NIR imaging using a radiolabeled or ICG-labeled a6b4 antibody.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27030400","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/1536012115624917","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"153-0121","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"U, Winn Aung"}],"nameIdentifiers":[{"nameIdentifier":"499600","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"499601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudo, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"499602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya"}],"nameIdentifiers":[{"nameIdentifier":"499603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"499604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ukai, Yoshinori"}],"nameIdentifiers":[{"nameIdentifier":"499605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurosawa, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"499606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"499607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｕ Ｗｉｎｎ Ａｕｎｇ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"499608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"499609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"499610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"499611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"499612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"499613","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-16"},"publish_date":"2019-01-16","publish_status":"0","recid":"49468","relation_version_is_last":true,"title":["Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:19:35.392414+00:00"}