{"created":"2023-05-15T14:38:13.445790+00:00","id":49325,"links":{},"metadata":{"_buckets":{"deposit":"9b5f23ef-3ccd-40c2-ab0a-817ce86d50a5"},"_deposit":{"created_by":1,"id":"49325","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49325"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049325","sets":["1"]},"author_link":["745497","745498","745491","745501","745495","745499","745502","745503","745504","745505","745496","745500","745492","745494","745493"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"546","bibliographicPageStart":"541","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Journal of radiation research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Anti-tumor immunity modulates the local effects of radiation therapy. High mobility group box 1 (HMGB1) plays a pivotal role in activating antigen-specific T-cell responses. Here, we examined the relationship between linear energy transfer (LET) and HMGB1 release. We assessed the proportions of KYSE-70, HeLa and SiHa cells surviving after carbon-ion (C-ion) beam irradiation with different LET values, using a clonogenic assay. The D10, the dose at which 10% of cells survived, was calculated using a linear-quadratic model. HMGB1 levels in the culture supernatants of C-ion beam-irradiated tumor cells were assessed by enzyme-linked immunosorbent assay. The D10 doses for 13 keV/μm of C-ion irradiation in KYSE-70, HeLa and SiHa cells were 2.8, 3.9 and 4.1 Gy, respectively, whereas those for 70 keV/μm C-ion irradiation were 1.4, 1.9 and 2.3 Gy, respectively. We found that 70 keV/μm of C-ion irradiation significantly increased HMGB1 levels in the culture supernatants of all cell lines 72 h after irradiation compared with non-irradiated controls. Furthermore, 70 keV/μm of C-ion irradiation significantly increased HMGB1 levels in the culture supernatants of all cell lines 72 h after irradiation compared with 13 keV/μm. The results suggest that HMGB1 release from several cancer cell lines increases with increased LET.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29947767","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rry049","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Onishi, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"745491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okonogi, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"745492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oike, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"745493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimoto, Yuya"}],"nameIdentifiers":[{"nameIdentifier":"745494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hiro"}],"nameIdentifiers":[{"nameIdentifier":"745495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"745496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"745497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"745498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Onishi, Masahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okonogi, Noriyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshimoto, Yuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745505","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"49325","relation_version_is_last":true,"title":["High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T01:18:05.025441+00:00"}