@article{oai:repo.qst.go.jp:00049315,
 author = {Keiko Li, Huizi and Hasegawa, Sumitaka and Izumi Nakajima, Nakako and Morokoshi, Yukie and Minegishi, Katsuyuki and Nagatsu, Kotaro and Li, Huizi and Hasegawa, Sumitaka and Nakajima, Nakako and Morokoshi, Yukie and Minegishi, Katsuyuki and Nagatsu, Kotaro},
 issue = {4},
 journal = {Biochemical and Biophysical Research Communications},
 month = {Nov},
 note = {Major histocompatibility complex class I chain-related protein A and B (MICA/B) are ligands of the immune receptor, natural-killer group 2 member D. MICA/B expression is often found in several types of cancer but is restricted in normal tissues. Here, we show that an α-particle emitting astatine-211 (211At)-
labeled antibody targeting MICA/B (211At-anti MICA/B Ab) efficiently ablates cancer cells in vitro and in vivo. We generated 211At-anti MICA/B Ab, an anti-MICA/B antibody conjugated with a highly cytotoxic  α-particle emitting radionuclide 211At. 211At-anti MICA/B Ab binds to human osteosarcoma SaOS2 and U2OS cells that exhibit high levels of MICA/B expression and efficiently kills those cells in vitro. Biodistribution analysis using xenograft mouse models of HCT116 p53-/- positive for MICA/B expression, showed increased 211At in the xenografts for up to 22 h after injection as time proceeded. A single dose of 211At-anti MICA/B Ab (1 MBq) showed significant reduction in the tumor growth rate of HCT116 p53-/- xenografts compared to 211At-labeled mouse IgG (1 MBq) at 21 days after injection. No body weight loss and erythrocytopenia was evident in mice that received 211At-anti MICA/B. Leukocytopenia and thrombocytopenia were observed within a week after 211At-anti MICA/B injection, but counts of red blood cells and platelets were recovered to control levels at about 3-4 weeks after injection. Taken together, these data strongly demonstrate that targeted  α-particle therapy using 211At-anti-MICA/B Ab emitting highly cytotoxic a-particles is a potential new therapeutic option for several types of cancer.},
 pages = {1078--1084},
 title = {Targeted cancer cell ablation in mice by an α-particle-emitting astatine-211-labeled antibody against major histocompatibility complex class I chain-related protein A and B},
 volume = {506},
 year = {2018}
}