{"created":"2023-05-15T14:38:10.372547+00:00","id":49255,"links":{},"metadata":{"_buckets":{"deposit":"4e7928fa-0de7-428a-a6bc-337b7578e8d9"},"_deposit":{"created_by":1,"id":"49255","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49255"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049255","sets":["1"]},"author_link":["745721","745727","745722","745719","745723","745720","745726","745718","745724","745725"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"33","bibliographicPageEnd":"22985","bibliographicPageStart":"22976","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Oncotarget"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Unresectable pediatric osteosarcoma has poor outcomes with conventional treatments.\nResults: Twenty-six patients aged 11-20 years (median 16) had inoperable osteosarcoma of the trunk (24 pelvic, 1 mediastinal and 1 paravertebral) without any other lesion at initial examination. There were 22 primary, 1 locally recurrent and 3 metastatic cases. Median CIRT dose was 70.4 Gy RBE (relative biological effectiveness) delivered in 16 fractions. Median follow-up was 32.7 months. Overall survival was 50.0% and 41.7% at 3 and 5 years, respectively. Ten patients survived for more than 5 years (range 5-20.7 years). Local control was 69.9% and 62.9% at 3 and 5 years, respectively and progression-free survival was 34.6% at 3 and 5 years. Only largest tumor diameter correlated with 5-year overall survival and local control. There were 4 grade 3-4 CIRT-related late toxicities, 1 case of bone fracture and no treatment-related mortalities. All patients (except 1) were able to ambulate after CIRT.\nConclusions: CIRT was safe and efficacious in the treatment of inoperable pediatric osteosarcoma with improved local control and overall survival compared to conventional treatments.\nMethods: We retrospectively reviewed the records of pediatric and adolescent patients who received carbon ion radiotherapy (CIRT) for inoperable osteosarcoma between 1996 and 2014.\n","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29796166","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.25165","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mohamad, Osama"}],"nameIdentifiers":[{"nameIdentifier":"745718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Reiko"}],"nameIdentifiers":[{"nameIdentifier":"745719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"745720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nitta, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"745721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Nobuhito"}],"nameIdentifiers":[{"nameIdentifier":"745722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mohamad, Osama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nitta, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Nobuhito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"745727","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Carbon ion radiotherapy for inoperable pediatric osteosarcoma.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon ion radiotherapy for inoperable pediatric osteosarcoma."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"49255","relation_version_is_last":true,"title":["Carbon ion radiotherapy for inoperable pediatric osteosarcoma."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T01:17:10.846848+00:00"}