{"created":"2023-05-15T14:38:08.975927+00:00","id":49223,"links":{},"metadata":{"_buckets":{"deposit":"b3a93f50-e865-4715-b701-b3fa08819227"},"_deposit":{"created_by":1,"id":"49223","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49223"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049223","sets":["1"]},"author_link":["758014","758002","758007","758011","758001","758004","758013","758016","758012","758009","758000","758008","757997","757999","758015","758010","758005","758006","757998","758003"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"8","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Clinical and Translational Radiation Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose: Carbon ion (C-ion) beams are concentrated to irradiate pancreatic carcinoma in the upper abdomen; however, this radiotherapy potentially causes adverse reactions in the gastrointestinal\ntract. FGF1 is a candidate radioprotector for radiation-induced intestinal damage, but may promote the malignancy of pancreatic cancer. An FGF1/CPP-C chimeric protein was created to enhance the intracellular\nsignaling mode of FGF1 instead of FGFR signaling. The present study investigated the effects of FGF1/CPP-C on the intestinal adverse reactions of C-ion radiotherapy as well as its influence on the malignancy of pancreatic cancer.\nMaterials and methods: FGF1/CPP-C was administered intraperitoneally to BALB/c mice without heparin 12 h before total body irradiation (TBI) with low-LET C-ion (17 keV/lm) at 6–8 Gy. Several radioprotective effects were examined in the jejunum. The invasion and migration of the human pancreatic carcinoma\ncell lines MIAPaCa-2 and PANC-1 were assessed using Boyden chambers after cultures with FGF1/CPP-C.\nResults: The FGF1/CPP-C treatment promoted crypt survival after C-ion irradiation at 7–8 Gy significantly more than the FGF1 treatment. FGF1/CPP-C also inhibited C-ion radiotherapy-induced apoptosis and reduced cH2AX foci in crypt cells more than FGF1. However, FGF1/CPP-C inhibited the downstream signaling pathways of FGFRs and suppressed the activation of cell-cycle regulatory molecules in the intestine until 4 h after TBI. Furthermore, IEC6 cells were arrested in G2M after cultures with FGF1/CPP-C or FGF1, suggesting that DNA repair after irradiation is promoted by FGF1/CPP-C-induced G2M arrest. In contrast, FGF1/CPP-C appeared to be internalized into MIAPaCa-2 and PANC-1 cells more efficiently than FGF1. Therefore, FGF1/CPP-C reduced the in vitro proliferation, invasion, and migration of MIAPaCa-2 and PANC-1 cells significantly more than FGF1 through the cellular internalization of FGF1.\nConclusion: These results suggest that the intracellular signaling mode of FGF1/CPP-C attenuates the intestinal adverse effects of C-ion radiotherapy without enhancing the malignancy of pancreatic carcinoma.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ctro.2018.10.004","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2405630818300715?via%3Dihub","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2405-6308","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川野, 光子"}],"nameIdentifiers":[{"nameIdentifier":"757997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三浦, 太一"}],"nameIdentifiers":[{"nameIdentifier":"757998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田, 真由美"}],"nameIdentifiers":[{"nameIdentifier":"757999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 幸子"}],"nameIdentifiers":[{"nameIdentifier":"758000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今留, 香織"}],"nameIdentifiers":[{"nameIdentifier":"758001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川, 敦子"}],"nameIdentifiers":[{"nameIdentifier":"758002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田, 武嗣"}],"nameIdentifiers":[{"nameIdentifier":"758003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今村, 亨"}],"nameIdentifiers":[{"nameIdentifier":"758004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 高志"}],"nameIdentifiers":[{"nameIdentifier":"758005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中山, 文明"}],"nameIdentifiers":[{"nameIdentifier":"758006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawano, Mitsuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Taichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imadome, Kaori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imamura, Toru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakayama, Fumiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"758016","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-30"},"publish_date":"2018-10-30","publish_status":"0","recid":"49223","relation_version_is_last":true,"title":["The FGF1/CPP-C chimera protein protects against intestinal adverse effects of C-ion radiotherapy without exacerbating pancreatic carcinoma"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:46:05.135798+00:00"}