@article{oai:repo.qst.go.jp:00049197, author = {Helm, Alexander and エブナー, ダニエル and ティンガネリ, ワルター and Simoniello, Palma and Bisio, Alessandra and Marchesano, Valentina and Durante, Marco and 山田, 滋 and 下川, 卓志 and Ebner, Daniel and Tinganelli, Walter and Yamada, Shigeru and Shimokawa, Takashi}, issue = {1}, journal = {International Journal of Particle Therapy}, month = {Sep}, note = {Clinical trials and case reports of cancer therapies combining radiation therapy with immunotherapy have at times demonstrated total reduction or elimination of metastatic disease. While virtually all trials focus on the use of immunotherapy combined with conventional photon irradiation, the dose-distributive benefits of particles, in particular the distinct biological effects of heavy ions, have unknown potential vis-a-vis systemic disease response. Here, we review recent developments and evidence with a focus on the potential for heavy-ion combination therapy.}, pages = {84--93}, title = {Combining Heavy-Ion Therapy with Immunotherapy: An Update on Recent Developments}, volume = {5}, year = {2018} }