@article{oai:repo.qst.go.jp:00049111,
 author = {Matsumoto, Yoshihiro and Shinoto, Makoto and Endo, Makoto and Setsu, Nokitaka and Iida, Keiichiro and Fukushi, Jun-Ichi and Kawaguchi, Kenichi and Okada, Seiji and Bekki, Hirofumi and Imai, Reiko and Kamada, Tadashi and Shioyama, Yoshiyuki and Nakashima, Yasuharu and 篠藤 誠 and 今井 礼子 and 鎌田 正 and 塩山 善之},
 journal = {BioMed Research International},
 month = {Jul},
 note = {Background and Purpose. Carbon-ion radiotherapy (C-ion RT) was effective therapy for inoperable spinal and paraspinal sarcomas. However, a significant adverse event following radiotherapies is vertebral compression fractures (VCFs). In this study, we investigated the incidence of and risk factors for post-C-ion RT VCFs in patients with spinal or paraspinal sarcomas. Material and Methods. Thirty consecutive patients with spinal or paraspinal sarcomas treated with C-ion RT were retrospectively reviewed. Various clinical parameters and the Spinal Instability Neoplastic Score (SINS) were used to evaluate the risk factors for post-C-ion RT VCFs. Results. The overall incidence of VCFs was 23% (median time: 7 months). Patients with VCFs showed a markedly higher SINS score (median value, 9 points) than those without VCF (5 points). The area under the receiver operating characteristic curve for the SINS score was 0.88, and the optimum SINS cut-off score was 8 points. The cumulative incidence of VCFs at 1 year was 9% for patients with a SINS score under 8 points, versus 80% for those with a SINS score of 8 points or higher (). Conclusions. In patients with a SINS score of 8 points or higher, referral to a spine surgeon for stabilization and multidisciplinary discussion is appropriate.},
 pages = {9467402-1--9467402-7},
 title = {Evaluation of Risk Factors for Vertebral Compression Fracture after Carbon-Ion Radiotherapy for Primary Spinal and Paraspinal Sarcoma.},
 volume = {2017},
 year = {2017}
}