@article{oai:repo.qst.go.jp:00049070,
 author = {Nitta, Nobuhiro and Takakusagi, Yoichi and Kokuryo, Daisuke and Shibata, Sayaka and Tomita, Akihiro and Higashi, Tatsuya and Aoki, Ichio and Harada, Masashi and Nitta, Nobuhiro and Takakusagi, Yoichi and Shibata, Sayaka and Higashi, Tatsuya and Aoki, Ichio},
 issue = {4},
 journal = {Nanomedicine},
 month = {Apr},
 note = {The enhanced permeability and retention (EPR) effect is variable depending on nanoparticle properties and tumor/vessel conditions. Thus, intratumoral evaluations of the vasculature and nanoparticle distribution are important for predicting the therapeutic efficacy and the intractability of tumors. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle delivery imaging using magnetic resonance (MR) micro-imaging technology with a gadolinium (Gd)-dendron assembled liposomal contrast agent. Using the Gd-liposome and a cryogenic receiving coil, we achieved 50-mum isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between Colon26- and SU-DHL6-grafted mice models. The vessel volumes and diameters measured for both tumors were significantly correlated with histological observations. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.},
 pages = {1315--1324},
 title = {Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging},
 volume = {14},
 year = {2018}
}