@article{oai:repo.qst.go.jp:00049057,
 author = {Tsunoda, Keiichiro and Yamashita, Toru and Shimada, Hitoshi and Nomura, Emi and Takahashi, Yoshiaki and Shang, Jingwei and Sato, Kota and Takemoto, Mami and Hishikawa, Nozomi and Ohta, Yasuyuki and Higuchi, Makoto and Suhara, Tetsuya and Kokubo, Yasumasa and Kuzuhara, Shigeki and Abe, Koji and 島田 斉 and 樋口 真人 and 須原 哲也},
 issue = {46},
 journal = {Journal of Clinical Neuroscience},
 month = {Sep},
 note = {Amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) is an endemic disease observed
in the Kii peninsula, Guam, and Papua. We report a case of a 76-year old man with ALS/PDC of the Kii
peninsula of Japan (Kii ALS/PDC). The patient was born and grew up in the Kii peninsula. He moved
out at age three, and developed symptoms 73 years later. He showed pyramidal sign, parkinsonian symptoms,
and mildly impaired cognitive function. 131I-metaiodobenzylguanidine myocardial scintigraphy
showed decreased cardiac sympathetic nerve function, and dopamine transporter single photon emission
computed tomography imaging showed decreased 123I-N-x-fluoropropyl-2b-carbomethoxy3b-(4-iodo
phenyl) nortropane accumulation. Cerebral blood flow showed hypoperfusion. Positron emission tomography
showed widespread tau deposition in his brain. This is a migration case of Kii ALS/PDC with the
shortest stay in the endemic area and the longest delay to develop the disease, indicating a genetic factor
for the disease development in a considerable degree.},
 pages = {64--67},
 title = {A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease},
 year = {2017}
}