{"created":"2023-05-15T14:38:01.371021+00:00","id":49050,"links":{},"metadata":{"_buckets":{"deposit":"a33d0272-3957-4938-bc99-b46b0f1cc0ad"},"_deposit":{"created_by":1,"id":"49050","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49050"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049050","sets":["1"]},"author_link":["494747","494750","494742","494748","494739","494741","494744","494740","494746","494738","494743","494749","494745"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1613","bibliographicPageStart":"1609","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medical Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract\nTyrosine kinase inhibitors for epidermal growth factor receptor (EGFR-TKIs) are used as molecular targeted therapy for non-small cell lung cancer (NSCLC) patients. The therapy is applied to the patients having EGFR-primary L858R mutation, but drug tolerance caused by EGFR-secondary mutation is occurred within one and half years. For the non-invasive detection of the EGFR-TKIs treatment positive patients by positron emission tomograpy (PET) imagaing, fluorine-18 labeled thienopyrimidine derivative, [18F]FTP2 was newly synthesized. EGFR inhibition assay, cell uptake study, and blocking study indicated [18F]FTP2 binds with high and selective affinity for EGFR with L858R mutation, and not with L858R/T790M dual mutations. On animal PET study using tumor bearing mice, H3255 cells expressing L858R mutated EGFR was more clearly visualized than H1975 cells expressing L858R/T790M dual mutated EGFR. [18F]FTP2 has potential for detecting NSCLC which is susceptible to EGFR-TKI treatment.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29478801","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bmc.2018.02.007","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1016/j.bmc.2018.02.007"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmc.2018.02.007","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makino, Akira"}],"nameIdentifiers":[{"nameIdentifier":"494738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Anna"}],"nameIdentifiers":[{"nameIdentifier":"494739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomoike, Ayaka"}],"nameIdentifiers":[{"nameIdentifier":"494740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"494741","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arimitsu, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"494742","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirata, Masahiko"}],"nameIdentifiers":[{"nameIdentifier":"494743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohmomo, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"494744","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishii, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"494745","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okazawa, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"494746","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kiyono, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"494747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"494748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saji, Hideo"}],"nameIdentifiers":[{"nameIdentifier":"494749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西井 龍一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"494750","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-18"},"publish_date":"2018-05-18","publish_status":"0","recid":"49050","relation_version_is_last":true,"title":["PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:21:30.512513+00:00"}