{"created":"2023-05-15T14:38:00.751194+00:00","id":49036,"links":{},"metadata":{"_buckets":{"deposit":"c1d9f7d4-2e13-4dcb-af22-a28cc1a895ef"},"_deposit":{"created_by":1,"id":"49036","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49036"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049036","sets":["1"]},"author_link":["743927","743932","743933","743931","743928","743929","743926","743930"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"4117","bibliographicPageStart":"4111","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Anticancer research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND/AIM:\nGlioblastoma is a frequent type of brain tumor and is radioresistant. Arsenite, which crosses the blood-brain barrier, shows synergistic effects with radiation in vitro and in vivo. The mechanism remains unclear.\nMATERIALS AND METHODS:\nAs synergistic radiosensitization has been reported in p53-deficient cancer cells, radiosensitization was evaluated using the glioblastoma cell line, U87MG-E6, which harbors inactivated p53, in comparison with the cell line, HCT116 p53 (-/-). Radiosensitivity was evaluated using clonogenic assays and detection of abnormal amplification of centrosomes (AAC).\nRESULTS:\nSynergistic effects of arsenite on radiosensitivity were observed in both cell lines. The radiosensitization induced by arsenite was abolished by N-acetyl-l-cysteine, a reactive oxygen species (ROS) scavenger. Increased radiosensitivity by arsenite was also abolished following knock-down of BRCA2. In addition, the increased radiosensitization by arsenite was correlated with AAC, which was abolished by BRCA2 knock-down.\nCONCLUSION:\nWe conclude that radiosensitization by arsenite is related to ROS and BRCA2 function.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28739695","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.21873/anticanres.11798","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":" 0250-7005","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二宮, 康晴"}],"nameIdentifiers":[{"nameIdentifier":"743926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"于, 冬"}],"nameIdentifiers":[{"nameIdentifier":"743927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関根, 絵美子"}],"nameIdentifiers":[{"nameIdentifier":"743928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島, 徹夫"}],"nameIdentifiers":[{"nameIdentifier":"743929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"743930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yu, Dong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"743931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sekine, Emiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"743932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"743933","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-14"},"publish_date":"2017-11-14","publish_status":"0","recid":"49036","relation_version_is_last":true,"title":["Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T01:34:20.058992+00:00"}