@article{oai:repo.qst.go.jp:00049036,
 author = {二宮, 康晴 and 于, 冬 and 関根, 絵美子 and 中島, 徹夫 and Ninomiya, Yasuharu and Yu, Dong and Sekine, Emiko and Nakajima, Tetsuo},
 issue = {8},
 journal = {Anticancer research},
 month = {May},
 note = {BACKGROUND/AIM:
Glioblastoma is a frequent type of brain tumor and is radioresistant. Arsenite, which crosses the blood-brain barrier, shows synergistic effects with radiation in vitro and in vivo. The mechanism remains unclear.
MATERIALS AND METHODS:
As synergistic radiosensitization has been reported in p53-deficient cancer cells, radiosensitization was evaluated using the glioblastoma cell line, U87MG-E6, which harbors inactivated p53, in comparison with the cell line, HCT116 p53 (-/-). Radiosensitivity was evaluated using clonogenic assays and detection of abnormal amplification of centrosomes (AAC).
RESULTS:
Synergistic effects of arsenite on radiosensitivity were observed in both cell lines. The radiosensitization induced by arsenite was abolished by N-acetyl-l-cysteine, a reactive oxygen species (ROS) scavenger. Increased radiosensitivity by arsenite was also abolished following knock-down of BRCA2. In addition, the increased radiosensitization by arsenite was correlated with AAC, which was abolished by BRCA2 knock-down.
CONCLUSION:
We conclude that radiosensitization by arsenite is related to ROS and BRCA2 function.},
 pages = {4111--4117},
 title = {Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells},
 volume = {37},
 year = {2018}
}