{"created":"2023-05-15T14:37:50.464048+00:00","id":48825,"links":{},"metadata":{"_buckets":{"deposit":"c851e3c1-5aa4-4961-a54c-ab90cb9a89de"},"_deposit":{"created_by":1,"id":"48825","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48825"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048825","sets":["1"]},"author_link":["491749","491757","491756","491753","491750","491754","491748","491755","491759","491752","491760","491758","491751"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"36","bibliographicPageEnd":"10629","bibliographicPageStart":"10626","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Angewandte Chemie (International ed. in English)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The γ-glutamyl transpeptidase (GGT) enzyme plays a central role in glutathione homeostasis. Direct detection of GGT activity could provide critical information for the diagnosis of several pathologies. We propose a new molecular probe, γ-Glu-[1-(13) C]Gly, for monitoring GGT activity in vivo by hyperpolarized (HP) (13) C magnetic resonance (MR). The properties of γ-Glu-[1-(13) C]Gly are suitable for in vivo HP (13) C metabolic analysis since the chemical shift between γ-Glu-[1-(13) C]Gly and its metabolic product, [1-(13) C]Gly, is large (4.3 ppm) and the T1 of both compounds is relatively long (30 s and 45 s, respectively, in H2 O at 9.4 T). We also demonstrate that γ-Glu-[1-(13) C]Gly is highly sensitive to in vivo modulation of GGT activity induced by the inhibitor acivicin.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-VCH"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27483206","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/anie.201603731","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1433-7851","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishihara, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"491748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A, I Yoshihara Hikari"}],"nameIdentifiers":[{"nameIdentifier":"491749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nonaka, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"491750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"491751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hyodo, Fuminori"}],"nameIdentifiers":[{"nameIdentifier":"491752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"491753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Can, Emine"}],"nameIdentifiers":[{"nameIdentifier":"491754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A, M Bastiaansen Jessica"}],"nameIdentifiers":[{"nameIdentifier":"491755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takado, Yuhei"}],"nameIdentifiers":[{"nameIdentifier":"491756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Comment, Arnaud"}],"nameIdentifiers":[{"nameIdentifier":"491757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sando, Shinsuke"}],"nameIdentifiers":[{"nameIdentifier":"491758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高堂 裕平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491760","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-26"},"publish_date":"2018-04-26","publish_status":"0","recid":"48825","relation_version_is_last":true,"title":["Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:23:54.263159+00:00"}