@article{oai:repo.qst.go.jp:00048825,
 author = {Nishihara, Tatsuya and A, I Yoshihara Hikari and Nonaka, Hiroshi and Takakusagi, Yoichi and Hyodo, Fuminori and Ichikawa, Kazuhiro and Can, Emine and A, M Bastiaansen Jessica and Takado, Yuhei and Comment, Arnaud and Sando, Shinsuke and 高草木 洋一 and 高堂 裕平},
 issue = {36},
 journal = {Angewandte Chemie (International ed. in English)},
 month = {Aug},
 note = {The γ-glutamyl transpeptidase (GGT) enzyme plays a central role in glutathione homeostasis. Direct detection of GGT activity could provide critical information for the diagnosis of several pathologies. We propose a new molecular probe, γ-Glu-[1-(13) C]Gly, for monitoring GGT activity in vivo by hyperpolarized (HP) (13) C magnetic resonance (MR). The properties of γ-Glu-[1-(13) C]Gly are suitable for in vivo HP (13) C metabolic analysis since the chemical shift between γ-Glu-[1-(13) C]Gly and its metabolic product, [1-(13) C]Gly, is large (4.3 ppm) and the T1 of both compounds is relatively long (30 s and 45 s, respectively, in H2 O at 9.4 T). We also demonstrate that γ-Glu-[1-(13) C]Gly is highly sensitive to in vivo modulation of GGT activity induced by the inhibitor acivicin.},
 pages = {10626--10629},
 title = {Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe.},
 volume = {55},
 year = {2016}
}