{"created":"2023-05-15T14:37:49.814943+00:00","id":48810,"links":{},"metadata":{"_buckets":{"deposit":"6d62f783-9d95-4715-b31b-4d2f1e2751c2"},"_deposit":{"created_by":1,"id":"48810","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48810"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048810","sets":["1"]},"author_link":["491594","491591","491593","491590","491589","491592","491588"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"15","bibliographicPageStart":"1","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Stem Cell Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mouse embryonic stem cells (ESCs) differentiate into multiple cell types during organismal development. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from ESCs via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) and extracellular signal-related kinase 1/2 (ERK1/2). The FGF4-MEK-ERK1/2 pathway is inhibited to maintain ESCs in the undifferentiated state. However, the inhibitory mechanism of the FGF4-MEK-ERK1/2 pathway in ESCs is uncharacterized. O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a post-translational modification characterized by the attachment of a single N-acetylglucosamine (GlcNAc) to the serine and threonine residues of nuclear or cytoplasmic proteins. Here, we showed that the O-GlcNAc on the phosphorylation site of PKCζ inhibits PKCζ phosphorylation (activation) and, consequently, the FGF4-PKCζ-MEK-ERK1/2 pathway in ESCs. Our results demonstrate the mechanism for the maintenance of the undifferentiated state of ESCs via the inhibition of the FGF4-PKCζ-MEK-ERK1/2 pathway by O-GlcNAcylation on PKCζ.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29249667","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.stemcr.2017.11.007. ","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30514-3#"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30514-3#","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2213-6711 ","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三浦, 太一"}],"nameIdentifiers":[{"nameIdentifier":"491588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"粂, 優彦"}],"nameIdentifiers":[{"nameIdentifier":"491589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川村, 猛"}],"nameIdentifiers":[{"nameIdentifier":"491590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本一夫"}],"nameIdentifiers":[{"nameIdentifier":"491591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浜窪, 隆雄"}],"nameIdentifiers":[{"nameIdentifier":"491592","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西原祥子"}],"nameIdentifiers":[{"nameIdentifier":"491593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三浦 太一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491594","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-25"},"publish_date":"2018-04-25","publish_status":"0","recid":"48810","relation_version_is_last":true,"title":["O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:04.037193+00:00"}