{"created":"2023-05-15T14:37:49.680503+00:00","id":48807,"links":{},"metadata":{"_buckets":{"deposit":"0b94195f-6b1c-4b13-a6ff-00acdc3719d7"},"_deposit":{"created_by":1,"id":"48807","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48807"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048807","sets":["1"]},"author_link":["491562","491564","491558","491559","491569","491568","491567","491563","491560","491557","491565","491561","491566"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1189","bibliographicPageStart":"1174","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"Stem Cell Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Regulatory dendritic cell (DCregs)-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs), which could remain in a \"stable immature stage\" even under strong stimulation. Harnessing this characteristic, we hypothesized that iPS-DCregs worked as a negative vaccine to generate regulatory T cells (Tregs), and induced donor-specific allograft acceptance. We immunized naive CBA (H-2Kk) mice with B6 (H-2Kb) iPS-DCregs and found that Tregs (CD4+CD25+FOXP3+) significantly increased in CBA splenocytes. Moreover, immunized CBA recipients permanently accepted B6 cardiac grafts in a donor-specific pattern. We demonstrated mechanistically that donor-type iPS-DCregs triggered transforming growth factor β1 secretion, under which the donor-antigen peptides directed naive CD4+ T cells to differentiate into donor-specific FOXP3+ Tregs instead of into effector T cells in vivo. These findings highlight the potential of iPS-DCregs as a key cell therapy resource in clinical transplantation.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28434942","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.stemcr.2017.03.020","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1016/j.stemcr.2017.03.020"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.stemcr.2017.03.020","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2213-6711 ","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Cai, Songjie"}],"nameIdentifiers":[{"nameIdentifier":"491557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hou, Jiangang"}],"nameIdentifiers":[{"nameIdentifier":"491558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujino, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"491559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Qi"}],"nameIdentifiers":[{"nameIdentifier":"491560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichimaru, Naotsugu"}],"nameIdentifiers":[{"nameIdentifier":"491561","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahara, Shiro"}],"nameIdentifiers":[{"nameIdentifier":"491562","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"491563","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lu, Lina"}],"nameIdentifiers":[{"nameIdentifier":"491564","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chen, Ji-Mei"}],"nameIdentifiers":[{"nameIdentifier":"491565","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhuang, Jian"}],"nameIdentifiers":[{"nameIdentifier":"491566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhu, Ping"}],"nameIdentifiers":[{"nameIdentifier":"491567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Xiao-Kang"}],"nameIdentifiers":[{"nameIdentifier":"491568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒木 良子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491569","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-25"},"publish_date":"2018-04-25","publish_status":"0","recid":"48807","relation_version_is_last":true,"title":["iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:06.122726+00:00"}