@article{oai:repo.qst.go.jp:00048807,
 author = {Cai, Songjie and Hou, Jiangang and Fujino, Masayuki and Zhang, Qi and Ichimaru, Naotsugu and Takahara, Shiro and Araki, Ryoko and Lu, Lina and Chen, Ji-Mei and Zhuang, Jian and Zhu, Ping and Li, Xiao-Kang and 荒木 良子},
 issue = {5},
 journal = {Stem Cell Reports},
 month = {Apr},
 note = {Regulatory dendritic cell (DCregs)-based immunotherapy is a potential therapeutic tool for transplant rejection. We generated DCregs from murine induced pluripotent stem cells (iPSCs), which could remain in a "stable immature stage" even under strong stimulation. Harnessing this characteristic, we hypothesized that iPS-DCregs worked as a negative vaccine to generate regulatory T cells (Tregs), and induced donor-specific allograft acceptance. We immunized naive CBA (H-2Kk) mice with B6 (H-2Kb) iPS-DCregs and found that Tregs (CD4+CD25+FOXP3+) significantly increased in CBA splenocytes. Moreover, immunized CBA recipients permanently accepted B6 cardiac grafts in a donor-specific pattern. We demonstrated mechanistically that donor-type iPS-DCregs triggered transforming growth factor β1 secretion, under which the donor-antigen peptides directed naive CD4+ T cells to differentiate into donor-specific FOXP3+ Tregs instead of into effector T cells in vivo. These findings highlight the potential of iPS-DCregs as a key cell therapy resource in clinical transplantation.},
 pages = {1174--1189},
 title = {iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells},
 volume = {8},
 year = {2017}
}