{"created":"2023-05-15T14:37:48.559193+00:00","id":48782,"links":{},"metadata":{"_buckets":{"deposit":"d32d544f-a745-45ce-920a-35bc55be0c68"},"_deposit":{"created_by":1,"id":"48782","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48782"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048782","sets":["1"]},"author_link":["491182","491181","491164","491180","491159","491173","491177","491176","491167","491184","491165","491169","491166","491174","491187","491188","491162","491185","491170","491160","491179","491161","491163","491183","491172","491171","491168","491178","491186","491175","491189"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"1052","bibliographicPageStart":"1037","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Journal of Alzheimer's Disease"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Tau imaging using PET is a promising tool for the diagnosis and evaluation of tau-related neurodegenerative disorders, but the relationship among PET-detectable tau, neuroinflammation and neurodegeneration is not yet fully understood. We aimed to elucidate sequential changes in tau accumulation, neuroinflammation and brain atrophy by PET and MRI in a tauopathy mouse model.  \nMethods: rTg4510 transgenic (tg) mice expressing P301L mutated tau and non-tg mice were examined with brain MRI and PET imaging (analyzed numbers: tg = 17, non-tg = 13; age 2.5~14 months). As PET probes, [11C]PBB3 (Pyridinyl-Butadienyl-Benzothiazole 3) and [11C]AC-5216 were used to visualize tau pathology and 18-kDa translocator protein (TSPO) neuroinflammation. Tau pathology and microglia activation were subsequently analyzed by histochemistry. \nResults: PET studies revealed age-dependent increases in [11C]PBB3 and [11C]AC-5216 signals, which were correlated with age-dependent volume reduction in the forebrain on MRI. However, the increase in [11C]PBB3 signals reached a plateau at age 7 months, and therefore its significant correlation with [11C]AC-5216 disappeared after age 7 months. In contrast, [11C]AC-5216 showed a strong correlation with both age and volume reduction until age 14 months. Histochemical analyses confirmed the relevance of pathological tau accumulation and elevated TSPO immunoreactivity in putative microglia.\nConclusion: Our results showed that tau accumulation is associated with neuroinflammation and brain atrophy in a tauopathy mouse model. The time-course of the [11C]PBB3- and TSPO-PET finding suggests that tau deposition triggers progressive neuroinflammation, and the sequential changes can be evaluated in vivo in mouse brains.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29332041","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3233/JAD-170509","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1387-2877","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Ai"}],"nameIdentifiers":[{"nameIdentifier":"491159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"491160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Jun"}],"nameIdentifiers":[{"nameIdentifier":"491161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamihisamatsu, Takeharu"}],"nameIdentifiers":[{"nameIdentifier":"491162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimojo, Masafumi"}],"nameIdentifiers":[{"nameIdentifier":"491163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuwa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"491164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"491165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ni, Ruiqing"}],"nameIdentifiers":[{"nameIdentifier":"491166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirano, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"491167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"491168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ji, Bin"}],"nameIdentifiers":[{"nameIdentifier":"491169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"491170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"491171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"491172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"491173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sahara, Naruhiko"}],"nameIdentifiers":[{"nameIdentifier":"491174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 愛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"徳永 正希","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南久松 丈晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下條 雅文","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 麻衣子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"倪 遑伯","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐原 成彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491189","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-23"},"publish_date":"2018-04-23","publish_status":"0","recid":"48782","relation_version_is_last":true,"title":["In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:22.330922+00:00"}