{"created":"2023-05-15T14:37:48.291022+00:00","id":48776,"links":{},"metadata":{"_buckets":{"deposit":"2d2849a7-9405-4e1f-b6cc-0f2e86468ed1"},"_deposit":{"created_by":1,"id":"48776","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48776"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048776","sets":["1"]},"author_link":["491076","491074","491073","491079","491080","491077","491078","491082","491081","491083","491072","491075"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"66","bibliographic_titles":[{"bibliographic_title":"Frontiers in neuroanatomy"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cortico-basal ganglia circuits are critical regulators of reward-based decision making.\nReinforcement learning models posit that action reward value is encoded by the\nfiring activity of striatal medium spiny neurons (MSNs) and updated upon changing\nreinforcement contingencies by dopamine (DA) signaling to these neurons. However,\nit remains unclear how the anatomically distinct direct and indirect pathways through\nthe basal ganglia are involved in updating action reward value under changing\ncontingencies. MSNs of the direct pathway predominantly express DA D1 receptors\nand those of the indirect pathway predominantly D2 receptors, so we tested for\ndistinct functions in behavioral adaptation by injecting D1 and D2 receptor antagonists\ninto the putamen of two macaque monkeys performing a free choice task for\nprobabilistic reward. In this task, monkeys turned a handle toward either a left or right\ntarget depending on an asymmetrically assigned probability of large reward. Reward\nprobabilities of left and right targets changed after 30–150 trials, so the monkeys were\nrequired to learn the higher-value target choice based on action–outcome history. In the\ncontrol condition, the monkeys showed stable selection of the higher-value target (that\nmore likely to yield large reward) and kept choosing the higher-value target regardless\nof less frequent small reward outcomes. The monkeys also made flexible changes of\nselection away from the high-value target when two or three small reward outcomes\noccurred randomly in succession. DA D1 antagonist injection significantly increased the\nprobability of the monkey switching to the alternate target in response to successive\nsmall reward outcomes. Conversely, D2 antagonist injection significantly decreased the\nswitching probability. These results suggest distinct functions of D1 and D2 receptormediated\nsignaling processes in action selection based on action–outcome history, with\nD1 receptor-mediated signaling promoting the stable choice of higher-value targets and\nD2 receptor-mediated signaling promoting a switch in action away from small reward\nFrontiers in Neuroanatomy | www.frontiersin.org 1 August 2017 | Volume 11 | Article 66\nUeda et al. D1, D2 Receptor Blockage\noutcomes. Therefore, direct and indirect pathways appear to have complementary\nfunctions in maintaining optimal goal-directed action selection and updating action value,\nwhich are dependent on D1 and D2 DA receptor signaling","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28824386","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3389/fnana.2017.00066","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://journal.frontiersin.org/article/10.3389/fnana.2017.00066/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Neuroanatomy&id=270734"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://journal.frontiersin.org/article/10.3389/fnana.2017.00066/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Neuroanatomy&id=270734","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueda, Yasumasa"}],"nameIdentifiers":[{"nameIdentifier":"491072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanaka, Ko"}],"nameIdentifiers":[{"nameIdentifier":"491073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noritake, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"491074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Enomoto, Kazuki"}],"nameIdentifiers":[{"nameIdentifier":"491075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"491076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"491077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Samejima, Kazuyuki"}],"nameIdentifiers":[{"nameIdentifier":"491078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inokawa, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"491079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hori, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"491080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Kae"}],"nameIdentifiers":[{"nameIdentifier":"491081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"491082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"堀 由紀子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491083","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-23"},"publish_date":"2018-04-23","publish_status":"0","recid":"48776","relation_version_is_last":true,"title":["Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:26.155414+00:00"}