@article{oai:repo.qst.go.jp:00048720, author = {Suefuji, Hiroaki and Koto, Masashi and Demizu, Yusuke and Saitoh, Jun-ichi and Shioyama, Yoshiyuki and Tsuji, Hiroshi and Okimoto, Tomoaki and Ohno, Tatsuya and Nemoto, Kenji and Nakano, Takashi and Kamada, Tadashi and 小藤 昌志 and 辻 比呂志 and 鎌田 正}, journal = {ANTICANCER RESEARCH International Journal of Cancer Research and Treatment}, month = {Mar}, note = {The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.}, pages = {1665--1670}, title = {A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas}, volume = {38}, year = {2018} }