{"created":"2023-05-15T14:37:44.144651+00:00","id":48681,"links":{},"metadata":{"_buckets":{"deposit":"7cad1394-bfe8-4335-9763-0a8502800e81"},"_deposit":{"created_by":1,"id":"48681","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48681"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048681","sets":["1"]},"author_link":["489791","489788","489780","489783","489793","489792","489782","489790","489795","489785","489794","489784","489786","489779","489789","489799","489778","489798","489796","489781","489797","489787"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"17","bibliographicPageStart":"12","bibliographicVolumeNumber":"158","bibliographic_titles":[{"bibliographic_title":"NeuroImage"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The central dopaminergic system is of major importance in the\npathophysiology of Parkinson’s disease, schizophrenia, and other\nneuropsychiatric disorders. In the present study, the normative data of\ndopaminergic neurotransmission functions in the midbrain, consisting of\nneuromelanin, dopamine synthesis, dopamine transporters and dopamine D2\nreceptors, were constructed using magnetic resonance (MR) imaging and\npositron emission tomography (PET). PET studies with L-[β-11C]DOPA,\n[18F]FE-PE2I and [11C]FLB457 and MRI studies were performed on healthy\nyoung men. Neuromelanin accumulation measured by MRI was compared with\ndopaminergic functions, dopamine synthesis capacity, dopamine transporter\nbinding and dopamine D2 receptor binding measured by PET in the substantia\nnigra. Although neuromelanin is synthesized from DOPA and dopamine in\ndopaminergic neurons, neuromelanin accumulation did not correlate with\ndopamine synthesis capacity in young healthy subjects. The role of dopamine\ntransporters in the substantia nigra is considered to be the transport of dopamine\ninto neurons, and therefore dopamine transporter binding might be related to\nneuromelanin accumulation; however, no significant correlation was observed\nbetween them. A positive correlation between dopamine D2 receptor binding and neuromelanin accumulation was observed, indicating a feedback mechanism by dopaminergic autoreceptors. Discrepancies in regional distribution between neuromelanin accumulation and dopamine synthesis capacity, dopamine transporter binding or dopamine D2 receptor binding were observed in the substantia nigra.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28655632","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuroimage.2017.06.066","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1053-8119","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"489778","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"489779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodaka, Fumitoshi"}],"nameIdentifiers":[{"nameIdentifier":"489780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takuwa, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"489781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"489782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"489783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"489784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"489785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubo, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"489786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Shiro"}],"nameIdentifiers":[{"nameIdentifier":"489787","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"489788","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"489789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川口 拓之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小高 文聰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田桑 弘之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"489799","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine  transporters, and dopamine D2 receptors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine  transporters, and dopamine D2 receptors"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-08"},"publish_date":"2018-04-08","publish_status":"0","recid":"48681","relation_version_is_last":true,"title":["Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine  transporters, and dopamine D2 receptors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:25:29.179745+00:00"}