@article{oai:repo.qst.go.jp:00048681,
 author = {Ito, Hiroshi and Kawaguchi, Hiroshi and Kodaka, Fumitoshi and Takuwa, Hiroyuki and Ikoma, Yoko and Shimada, Hitoshi and Kimura, Yasuyuki and Seki, Chie and Kubo, Hitoshi and Ishii, Shiro and Takano, Harumasa and Suhara, Tetsuya and 伊藤 浩 and 川口 拓之 and 小高 文聰 and 田桑 弘之 and 生駒 洋子 and 島田 斉 and 木村 泰之 and 関 千江 and 高野 晴成 and 須原 哲也},
 journal = {NeuroImage},
 month = {Jun},
 note = {The central dopaminergic system is of major importance in the
pathophysiology of Parkinson’s disease, schizophrenia, and other
neuropsychiatric disorders. In the present study, the normative data of
dopaminergic neurotransmission functions in the midbrain, consisting of
neuromelanin, dopamine synthesis, dopamine transporters and dopamine D2
receptors, were constructed using magnetic resonance (MR) imaging and
positron emission tomography (PET). PET studies with L-[β-11C]DOPA,
[18F]FE-PE2I and [11C]FLB457 and MRI studies were performed on healthy
young men. Neuromelanin accumulation measured by MRI was compared with
dopaminergic functions, dopamine synthesis capacity, dopamine transporter
binding and dopamine D2 receptor binding measured by PET in the substantia
nigra. Although neuromelanin is synthesized from DOPA and dopamine in
dopaminergic neurons, neuromelanin accumulation did not correlate with
dopamine synthesis capacity in young healthy subjects. The role of dopamine
transporters in the substantia nigra is considered to be the transport of dopamine
into neurons, and therefore dopamine transporter binding might be related to
neuromelanin accumulation; however, no significant correlation was observed
between them. A positive correlation between dopamine D2 receptor binding and neuromelanin accumulation was observed, indicating a feedback mechanism by dopaminergic autoreceptors. Discrepancies in regional distribution between neuromelanin accumulation and dopamine synthesis capacity, dopamine transporter binding or dopamine D2 receptor binding were observed in the substantia nigra.},
 pages = {12--17},
 title = {Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine  transporters, and dopamine D2 receptors},
 volume = {158},
 year = {2017}
}