@article{oai:repo.qst.go.jp:00048659,
 author = {長澤, 尚胤 and 木村, 敦 and 出崎, 亮 and 山田, 尚人 and 江夏, 昌志 and 佐藤, 隆博 and 石井, 保行 and 田口, 光正 and 長澤 尚胤 and 木村 敦 and 出崎 亮 and 山田 尚人 and 江夏 昌志 and 佐藤 隆博 and 石井 保行 and 田口 光正},
 journal = {Nuclear Instruments and Methods in Physics Research B},
 month = {Oct},
 note = {Functionalization of biocompatible materials is expected to be widely applied in biomedical engineering and regenerative medicine fields. Hydrogel has been expected as a biocompatible scaffold which support to keep an organ shape during cell multiplying in regenerative medicine. Therefore, it is important to understanding a surface microstructure (minute shape, depth of flute) and a chemical characteristic of the hydrogel affecting the cell culture. Here, we investigate the microfabrication of biocompatible polymeric materials, such as the water-soluble polysaccharide derivatives hydroxypropyl cellulose and carboxymethyl cellulose, by use of proton beam writing (PBW). These polymeric materials were dissolved thoroughly in pure water using a planetary centrifugal mixer, and a sample sheet (1 mm thick) was formed on polyethylene terephthalate (PET) film. Crosslinking to form hydrogels was induced using a
3.0 MeV focused proton beam from the single-ended accelerator at Takasaki Ion Accelerators for Advanced Radiation Application. The aqueous samples were horizontally irradiated with the proton beam through the PET cover film, and then rinsed with deionized water. Microstructured hydrogels were obtained on the PET film using the PBW technique without toxic crosslinking reagents. Cell adhesion and proliferation on the microfabricated biocompatible hydrogels were investigated. Microfabrication of HPC and CMC by the use of PBW is expected to produce new biocompatible materials that can be applied in biological and medical applications.},
 pages = {102--106},
 title = {Microfabrication of biocompatible hydrogel by proton beam writing},
 volume = {409},
 year = {2017}
}