{"created":"2023-05-15T14:37:41.724381+00:00","id":48626,"links":{},"metadata":{"_buckets":{"deposit":"910cb52b-14aa-48cc-992c-6fdab05402fb"},"_deposit":{"created_by":1,"id":"48626","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48626"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048626","sets":["1"]},"author_link":["901551","901549","901559","901550","901548","901553","901554","901557","901556","901555","901552","901558"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"e0178472-13","bibliographicPageStart":"e0178472-1","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"PLOS ONE"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, 211At has received increasing attention as a potential radionuclide for cancer radioimmunotherapy. It is a α-particle emitter, which is extremely effective against malignant cells. We demonstrate a method to verify the efficiency of 211At-labeled trastuzumab antibodies (211At-trastuzumab) against HER2 antigens, which has not been determined for radioimmunotherapy. A CR-39 plastic nuclear detector is used for measuring the position and the linear energy transfer (LET) of individual 211At α- particle tracks. The tracks and 211At-trastuzumab-binding cells were co-visualized by using the geometric information recorded on the CR-39. HER2-positive human gastric cancer cells (NCI-N87), labelled with 211At-trastuzumab, were dropped on the centre of the CR-39 plate. Microscope images of the cells and the corresponding α-tracks acquired by position matching were obtained. In addition, 3.5 cm × 3.5 cm macroscopic images of the whole plate were acquired. The distribution of number of α-particles emitted from single cells suggests that 80% of the 211At-trastuzumab-binding cells emitted α-particles. It also indicates that the α-particles may strike the cells several times along their path. The track-averaged LET of the α-particles is evaluated to be 131 keV/μm. These results will enable quantitative evaluation of delivered doses to target cells, and will be useful for the in vitro assessment of 211At-based radioimmunotherapeutic agents.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1371/journal.pone.0178472","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178472","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kodaira, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"901548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Huizi"}],"nameIdentifiers":[{"nameIdentifier":"901549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"901550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KItamura, Hisashi"}],"nameIdentifiers":[{"nameIdentifier":"901551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurano, Mieko"}],"nameIdentifiers":[{"nameIdentifier":"901552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka"}],"nameIdentifiers":[{"nameIdentifier":"901553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kodaira, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Huizi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamura, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901557","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurano, Mieko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"901559","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Validating α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Validating α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-30"},"publish_date":"2017-06-30","publish_status":"0","recid":"48626","relation_version_is_last":true,"title":["Validating α-particle emission from 211At-labeled antibodies in single cells for cancer radioimmunotherapy using CR-39 plastic nuclear track detectors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:16:19.149854+00:00"}