@article{oai:repo.qst.go.jp:00048542,
 author = {Tokuda, Yusuke and Sakakibara, Mamoru and Yoshinaga, Keiichiro and Yamada, Shiro and Kamiya, Kiwamu and Asakawa, Naoya and Yoshitani, Takashi and Noguchi, Keiji and Manabe, Osamu and Tamaki, Nagara and Tsutsui, Hiroyuki and Yoshinaga, Keiichiro},
 issue = {4},
 journal = {Journal of Nuclear Cardiology},
 month = {Nov},
 note = {Rationale
Adaptive servo-ventilation (ASV), a novel respiratory support therapy for sleep disorders, may improve cardiac function in heart failure (HF). However, the reasons that ASV improves cardiac function have not been fully studied especially in sympathetic nervous function (SNF). The purpose of the present study was to investigate the effects of ASV therapy on cardiac SNF in patients with HF.
Methods
We evaluated ASV therapeutic effects before and 6 months after ASV therapy in 9 HF patients [57.3 ± 17.3 years old, left ventricular ejection fraction (LVEF) 36.1 ± 16.7%]. We performed echocardiography, polysomnography, biomarkers, 11C-hydroxyephedrine (HED) PET as a presynaptic function marker and planar 123I-metaiodobenzylguanidine (MIBG) to evaluate washout rate.
Results
ASV therapy reduced apnea-hypopnea index (AHI) and improved plasma brain natriuretic peptide (BNP) concentration. In 123I-MIBG imaging, the early heart/mediastinum (H/M) ratio increased after ASV therapy (2.19 ± 0.58 to 2.40 ± 0.67; P = 0.045). Washout rate did not change (23.8 ± 7.3% to 23.8 ± 8.8%; P = 0.122). Global 11C-HED retention index (RI) improved from 0.068 ± 0.033/s to 0.075 ± 0.034/s (P = 0.029).
Conclusions
ASV reduced AHI and improved BNP. ASV might initially improve presynaptic cardiac sympathetic nervous function in HF patients after 6 months of treatment.},
 pages = {1079--1089},
 title = {Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination of 11C-HED PET and 123I-MIBG SPECT.},
 volume = {26},
 year = {2017}
}