@article{oai:repo.qst.go.jp:00048529, author = {Imai, Kohei and Nakanishi, Ikuo and Ohno, Akiko and Kurihara, Masaaki and Miyata, Naoki and Matsumoto, Ken-Ichiro and Nakamura, Asao and Fukuhara, Kiyoshi and 今井 耕平 and 中西 郁夫 and 大野 彰子 and 松本 謙一郎}, issue = {11}, journal = {Bioorganic & Medicinal Chemistry Letters}, month = {Mar}, note = {Catechin analogue 1 with methyl substituents ortho to the catechol hydroxyl groups was synthesized to improve the antioxidant ability of (+)-catechin. The synthetic scheme involved a solid acid catalyzed Friedel-Crafts coupling of a cinnamyl alcohol derivative to 3,5-dibenzyloxyphenol followed by hydroxylation and then cyclization through an intermediate orthoester. The antioxidative radical scavenging activity of 1 against galvinoxyl radical, an oxyl radical, was found to be 28-fold more potent than (+)-catechin.}, pages = {2582--2584}, title = {Synthesis and Radical-Scavenging Activity of a Dimethylcatechin Analogue}, volume = {24}, year = {2014} }