{"created":"2023-05-15T14:37:36.923337+00:00","id":48526,"links":{},"metadata":{"_buckets":{"deposit":"ba709c8f-dc91-4bed-a920-5cda39e1121a"},"_deposit":{"created_by":1,"id":"48526","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48526"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048526","sets":["1"]},"author_link":["487791","487794","487789","487793","487797","487795","487796","487798","487792","487790"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"20","bibliographicPageEnd":"6739","bibliographicPageStart":"6733","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"S-Nitrosoglutathione (GSNO) relaxes vascular smooth muscles, prevents platelet aggregation, and acts as a potential in vivo nitric oxide donor.  3-Nitroso-1,3-thiazolidine- 4-thiocarboxamide (1), a N-nitrosothioproline analogue, exhibited a high GSNO formation activity.  In this study, two compounds (2 and 3) based on compound 1 were newly synthesized by introducing either one or two methyl groups onto a nitrogen atom on the thioamide substituent in 1.  The pseudo-first-order rate constants (kobs) for the GSNO formation for the reaction between the compound and glutathione (GSH) followed the orde 1 > 2 ≈ 3.  Thus, the introduction of a methyl group(s) onto the thioamide group led to a decrease in the transnitrosation activity.  On the basis of density functional theoretical calculations, the transnitrosation for the N-nitrosothiazolidine thiocarboxamides was proposed to proceed via a bridged intermediate pathway.  Specifically, the protonated compound 1 forms a bridged structure between the nitrogen atom in the nitroso group and two sulphur atoms–one in the ring and the other in the substituent.  The bridged intermediate gives rise to a second intermediate, in which the nitroso group is bonded to the sulphur atom in the thioamide group.  Finally, the nitroso group is transferred to GSH to form GSNO.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26386820","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bmc.2015.09.008","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/article/pii/S096808961530033X"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S096808961530033X","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0968-0896","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inami, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"487789","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Yuta"}],"nameIdentifiers":[{"nameIdentifier":"487790","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Sonoe"}],"nameIdentifiers":[{"nameIdentifier":"487791","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"487792","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Kei"}],"nameIdentifiers":[{"nameIdentifier":"487793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuzumi, Shunichi"}],"nameIdentifiers":[{"nameIdentifier":"487794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mochizuki, Masataka"}],"nameIdentifiers":[{"nameIdentifier":"487795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲見 圭子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487798","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Alkyl Group on Transnitrosation of N-Nitrosothiazolidine Thiocarboxamides","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Alkyl Group on Transnitrosation of N-Nitrosothiazolidine Thiocarboxamides"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-20"},"publish_date":"2018-02-20","publish_status":"0","recid":"48526","relation_version_is_last":true,"title":["Effect of Alkyl Group on Transnitrosation of N-Nitrosothiazolidine Thiocarboxamides"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:27:08.828653+00:00"}