{"created":"2023-05-15T14:37:31.581645+00:00","id":48405,"links":{},"metadata":{"_buckets":{"deposit":"947dc6d8-2745-41c6-9f90-2a5bbaf7a4ce"},"_deposit":{"created_by":1,"id":"48405","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48405"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048405","sets":["1"]},"author_link":["486556","486545","486543","486541","486546","486540","486551","486544","486550","486548","486552","486553","486554","486555","486557","486547","486542","486549"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"21","bibliographicPageEnd":"4897","bibliographicPageStart":"4893","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Upregulated monocarboxylate transporters (MCTs) in tumors are considered diagnostic imaging targets.\nHerein, we synthesized the positron emission tomography probe candidates coumarin analogs 2 and 3,\nand showed 55 times higher affinity of 2 for MCTs than a representative MCT inhibitor. Whereas [11C]\n2 showed low tumor accumulation, probably due to adduct formation with plasma proteins, [11C]2\nshowed high initial brain uptake, suggesting that the scaffold of 2 has properties that are preferable in\nimaging probes for the astrocyte–neuron lactate shuttle. Although further optimization of 2 is required,\nour findings can be used to inform the development of MCT-targeted imaging agents.\n  2017 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28951078","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bmcl.2017.09.033","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tateishi, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"486540","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"486541","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"486542","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudo, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"486543","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya"}],"nameIdentifiers":[{"nameIdentifier":"486544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanakawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"486545","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"486546","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"486547","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasushi, Arano"}],"nameIdentifiers":[{"nameIdentifier":"486548","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"486549","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"立石 裕行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486550","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486551","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 孝一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須藤 仁美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486554","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486556","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486557","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-12-06"},"publish_date":"2017-12-06","publish_status":"0","recid":"48405","relation_version_is_last":true,"title":["Synthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:28:29.131596+00:00"}