@article{oai:repo.qst.go.jp:00048383,
 author = {Nakayama, Fumiaki and Hagiwara, Akiko and Umeda, Sachiko and Asada, Masahiro and Goto, Megumi and Oki, Junko and Suzuki, Masashi and Imamura, Toru and Akashi, Makoto and 中山 文明 and 萩原 亜紀子 and 梅田 禎子 and 明石 真言},
 issue = {3},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Nov},
 note = {PURPOSE: A fibroblast growth factor (FGF) 1-FGF2 chimera (FGFC) was created previously and showed greater structural stability than FGF1. This chimera was capable of stimulating epithelial cell proliferation much more strongly than FGF1 or FGF2 even without heparin. Therefore FGFC was expected to have greater biologic activity in vivo. This study evaluated and compared the protective activity of FGFC and FGF1 against radiation-induced intestinal injuries.
METHODS AND MATERIALS: We administered FGFC and FGF1 intraperitoneally to BALB/c mice 24 h before or after total-body irradiation (TBI). The numbers of surviving crypts were determined 3.5 days after TBI with gamma rays at doses ranging from 8 to 12 Gy.
RESULTS: The effect of FGFC was equal to or slightly superior to FGF1 with heparin. However, FGFC was significantly more effective in promoting crypt survival than FGF1 (p < 0.01) when 10 micrograms of each FGF was administered without heparin before irradiation. In addition, FGFC was significantly more effective at promoting crypt survival (p < 0.05) than FGF1 even when administered without heparin at 24 h after TBI at 10, 11, or 12 Gy. We found that FGFC post treatment significantly promoted 5-bromo-2'-deoxyuridine incorporation into crypts and increased crypt depth, resulting in more epithelial differentiation. However, the number of apoptotic cells in FGFC-treated mice decreased to almost the same level as that in FGF1-treated mice.},
 pages = {860--867},
 title = {POST TREATMENT WITH AN FGF CHIMERIC GROWTH FACTOR ENHANCES EPITHELIAL CELL PROLIFERATION TO IMPROVE RECOVERY FROM RADIATION-INDUCED INTESTINAL DAMAGE},
 volume = {78},
 year = {2010}
}