{"created":"2023-05-15T14:37:30.495675+00:00","id":48380,"links":{},"metadata":{"_buckets":{"deposit":"9a7be3de-737f-4076-b3f3-207c65dff63b"},"_deposit":{"created_by":1,"id":"48380","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48380"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048380","sets":["1"]},"author_link":["486262","486261","486258","486257","486265","486266","486263","486268","486256","486259","486267","486260","486264"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"237","bibliographicPageStart":"231","bibliographicVolumeNumber":"587","bibliographic_titles":[{"bibliographic_title":"FEBS Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study focuses on clarifying the contribution of sulfation to radiation-induced apoptosis in human Burkitt's lymphoma cell lines, using 3'-phosphoadenosine 5'-phosphosulfate transporters (PAPSTs). Overexpression of PAPST1 or PAPST2 reduced radiation-induced apoptosis in Namalwa cells, whereas the repression of PAPST1 expression enhanced apoptosis. Inhibition of PAPST slightly decreased keratan sulfate (KS) expression, so that depletion of KS significantly increased radiation-induced apoptosis. In addition, the repression of all three N-acetylglucosamine-6-O-sulfotransferases (CHST2, CHST6, and CHST7) increased apoptosis. In contrast, PAPST1 expression promoted the phosphorylation of p38 MAPK and Akt in irradiated Namalwa cells. These findings suggest that 6-O-sulfation of GlcNAc residues in KS reduces radiation-induced apoptosis of human Burkitt's lymphoma cells.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.febslet.2012.12.002.","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/article/pii/S0014579312009040"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S0014579312009040","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-5793","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakayama, Fumiaki"}],"nameIdentifiers":[{"nameIdentifier":"486256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Umeda, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"486257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichimiya, Tomomi"}],"nameIdentifiers":[{"nameIdentifier":"486258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiyama, Shin"}],"nameIdentifiers":[{"nameIdentifier":"486259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hazawa, Masaharu"}],"nameIdentifiers":[{"nameIdentifier":"486260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"486261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishihara, Shoko"}],"nameIdentifiers":[{"nameIdentifier":"486262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"486263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中山 文明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"梅田 禎子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽澤 勝治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 武嗣","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486268","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-22"},"publish_date":"2017-11-22","publish_status":"0","recid":"48380","relation_version_is_last":true,"title":["Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:28:46.884879+00:00"}