@article{oai:repo.qst.go.jp:00048380,
 author = {Nakayama, Fumiaki and Umeda, Sachiko and Ichimiya, Tomomi and Kamiyama, Shin and Hazawa, Masaharu and Yasuda, Takeshi and Nishihara, Shoko and Imai, Takashi and 中山 文明 and 梅田 禎子 and 羽澤 勝治 and 安田 武嗣 and 今井 高志},
 issue = {2},
 journal = {FEBS Letters},
 month = {Dec},
 note = {This study focuses on clarifying the contribution of sulfation to radiation-induced apoptosis in human Burkitt's lymphoma cell lines, using 3'-phosphoadenosine 5'-phosphosulfate transporters (PAPSTs). Overexpression of PAPST1 or PAPST2 reduced radiation-induced apoptosis in Namalwa cells, whereas the repression of PAPST1 expression enhanced apoptosis. Inhibition of PAPST slightly decreased keratan sulfate (KS) expression, so that depletion of KS significantly increased radiation-induced apoptosis. In addition, the repression of all three N-acetylglucosamine-6-O-sulfotransferases (CHST2, CHST6, and CHST7) increased apoptosis. In contrast, PAPST1 expression promoted the phosphorylation of p38 MAPK and Akt in irradiated Namalwa cells. These findings suggest that 6-O-sulfation of GlcNAc residues in KS reduces radiation-induced apoptosis of human Burkitt's lymphoma cells.},
 pages = {231--237},
 title = {Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines},
 volume = {587},
 year = {2012}
}