{"created":"2023-05-15T14:37:30.147112+00:00","id":48372,"links":{},"metadata":{"_buckets":{"deposit":"988b933a-fd16-4595-bbee-09254cc1771d"},"_deposit":{"created_by":1,"id":"48372","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48372"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048372","sets":["1"]},"author_link":["486176","486181","486175","486177","486178","486179","486184","486185","486186","486187","486188","486189","486180","486183","486190","486182"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"91-7","bibliographicPageStart":"91-1","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Radiation Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\n\\nCarbon-ion radiotherapy (CIRT) is a promising treatment for locally advanced non-small-cell lung cancer, especially for patients with inoperable lung cancer. Although the incidence of CIRT-induced radiation pneumonitis (RP) ≥ grade 2 ranges from 2.5 to 9.9%, the association between CIRT-induced RP and dosimetric parameters is not clear. Herein, we identified prognostic factors associated with symptomatic RP after CIRT for patients with non-small-cell lung cancer.\n\\n\nMethods\n\\nClinical results of 65 patients treated with CIRT between 2000 and 2015 at the National Institute of Radiological Sciences were retrospectively analyzed. Clinical stage II B disease (TNM classification) was the most common stage among the patients (45%). The median radiation dose was 72 Gy (68–76) relative biological effectiveness (RBE) in 16 fractions. In cases involving metastatic lymph nodes, prophylactic irradiation of mediastinal lymph nodes was performed at a median dose of 49.5 Gy (RBE). The median follow-up was 22 months.\n\\n\nResults\n\\nGrade 2 and grade 3 RP occurred in 6 and 3 patients (9 and 5%), respectively. No patients developed grade 4 or 5 RP. Using univariate analysis, vital capacity as a percentage of predicted (%VC), forced expiratory volume in 1 s (FEV1), mean lung dose (MLD), volume of lung receiving ≥5 Gy (RBE) (V5), V10, V20 and V30 were determined to be the significant predictive factors for ≥ grade 2 RP. The receiver operating characteristic (ROC) analysis revealed the cutoff values for %VC, FEV1, MLD, V5, V10, V20 and V30 for ≥ grade 2 RP, which were 86.9%, 1.16 L, 12.5 Gy (RBE), 28.8, 29.9, 20.1 and 15.0%, respectively. In addition, the multivariate analysis revealed that %VC <86.9% (odds ratio = 13.7; p = 0.0041) and V30 ≥ 15% (odds ratio = 6.1; p = 0.0221) were significant risk factors.\n\\n\nConclusions\n\\nOur study demonstrated the risk factors for ≥ grade 2 RP after carbon-ion radiotherapy for patients with locally advanced lung cancer.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28558766","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13014-017-0830-z","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1186/s13014-017-0830-z"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s13014-017-0830-z","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1748-717X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashi, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"486175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Naoyoshi"}],"nameIdentifiers":[{"nameIdentifier":"486176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karube, Masataka"}],"nameIdentifiers":[{"nameIdentifier":"486177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Mio"}],"nameIdentifiers":[{"nameIdentifier":"486178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"486179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"486180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"486181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"486182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486183","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本 直敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486184","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"軽部 雅崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486185","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中嶋 美緒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486186","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松藤 成弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486187","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 比呂志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486188","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486189","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486190","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic analysis of radiation pneumonitis: carbon-ion radiotherapy in patients with locally advanced lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic analysis of radiation pneumonitis: carbon-ion radiotherapy in patients with locally advanced lung cancer"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"48372","relation_version_is_last":true,"title":["Prognostic analysis of radiation pneumonitis: carbon-ion radiotherapy in patients with locally advanced lung cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:28:52.605259+00:00"}