{"created":"2023-05-15T14:37:30.104018+00:00","id":48371,"links":{},"metadata":{"_buckets":{"deposit":"1e7460fd-3c6a-41f9-8f4c-cb59d3276a16"},"_deposit":{"created_by":1,"id":"48371","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48371"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048371","sets":["1"]},"author_link":["486164","486174","486163","486167","486168","486161","486173","486162","486165","486171","486169","486172","486170","486166"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1072","bibliographicPageEnd":"20160790-7","bibliographicPageStart":"20160790-1","bibliographicVolumeNumber":"90","bibliographic_titles":[{"bibliographic_title":"The British Institute of Radiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"OBJECTIVE: \n\\nPancreatic cancer is a difficult to treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous integrated boost (SIB) to increase tumour dose, sparing organs at risk (OARs).\n\\nMETHODS: \n\\nUsing four-dimensional CT data of 12 patients, we delineated gross tumour volume and two clinical target volumes (CTVs). To consider beam range intrafractional uncertainty, we calculated field-specific target volumes, from which two planning target volumes (PTVs) were generated. PTV1 would receive a planned dose of 55.2 Gy [relative biological effectiveness (RBE)-weighted absorbed dose] in 12 fractions, and PTV2 would receive an SIB dose up to 67.2 Gy (RBE). Dose assessments were conducted with regard to the targets and OARs.\n\\nRESULTS: \n\\nCTV2 dose covering 95% of the volume (D95%) increased from 50.3 ± 5.1 Gy (RBE) to 62.5 ± 3.5 Gy (RBE) for a planned dose from 55.2 Gy (RBE) to 67.2 Gy (RBE). For 4 of 12 patients with a distance of ≥5 mm between the tumour and the gastrointestinal tract, CTV2 D95% was ≥95% of planned dose at all dose levels.\n\\nCONCLUSION: \n\\nWe quantified dose escalation with respiratory-gated C-PBS using SIB for pancreatic cancer and revealed that OAR dose was not affected to the same degree as the tumour dose. Advances in knowledge: A simulation study on respiratory-gated C-PBS with SIB for pancreatic cancer was performed. The results indicated the feasibility of dose escalation for pancreatic cancer, which should be confirmed in clinical trials.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28181819","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1259/bjr.20160790 ","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1259/bjr.20160790"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1259/bjr.20160790","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0007-1285","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawashiro, Shohei"}],"nameIdentifiers":[{"nameIdentifier":"486161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"486162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"486163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miki, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"486164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nemoto, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"486165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"486166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"486167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川城 壮平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森 慎一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三木 一弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根本 建二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 比呂志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486174","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-16"},"publish_date":"2017-11-16","publish_status":"0","recid":"48371","relation_version_is_last":true,"title":["Dose escalation study with respiratory-gated carbon-ion scanning radiotherapy using a simultaneous integrated boost for pancreatic cancer: simulation with four-dimensional computed tomography."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:28:53.330413+00:00"}