{"created":"2023-05-15T14:37:29.277711+00:00","id":48352,"links":{},"metadata":{"_buckets":{"deposit":"6019158d-5023-4000-b319-45709c0df241"},"_deposit":{"created_by":1,"id":"48352","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48352"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048352","sets":["1"]},"author_link":["485934","485935"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageStart":"310","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Journal of Alzheimer's Disease & Parkinsonism"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"a-シヌクレイン（aSyn）は、アミロイド線維と呼ばれる繊維状の異常凝集体を形成する。この異常凝集体形成がパーキンソン病発症と深い関係を持つ。従って、パーキンソン病発症機構解明のためにはaSynのアミロイド線維形成機構の解明が重要である。本解説では、我々が行ったaSynの中性子準弾性散乱実験から得られた、単量体状態のaSynおよび線維状態のaSynのダイナミクスの特徴について記述する。そして、特に線維状態でのaSynのふるまいが、パーキンソン病発症といかに関係しうるかについて議論する。","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.4172/2161-0460.1000310","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2161-0460","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤原, 悟"}],"nameIdentifiers":[{"nameIdentifier":"485934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤原 悟","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"485935","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Dynamic aspects of amyloid fibrils of a-synuclein related to the pathogenesis of Parkinson's disease ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dynamic aspects of amyloid fibrils of a-synuclein related to the pathogenesis of Parkinson's disease "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-02"},"publish_date":"2017-11-02","publish_status":"0","recid":"48352","relation_version_is_last":true,"title":["Dynamic aspects of amyloid fibrils of a-synuclein related to the pathogenesis of Parkinson's disease "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:29:05.693608+00:00"}