@article{oai:repo.qst.go.jp:00048230,
 author = {Yu, Hao and S, Haskins Jeremy and Su, Cathy and Allum, Allison and H, Haskins Alexis and A, Salinas Victoria and Sunada, Shigeaki and Inoue, Taisuke and Aizawa, Yasushi and Uesaka, Mitsuru and A, Kato Takamitsu and 砂田 成章 and 井上 泰助 and 相澤 恭 and 上坂 充},
 issue = {5},
 journal = {International journal of molecular medicine},
 month = {Nov},
 note = {Novel glucosyl flavonoids are developed by the addition of glucose to naturally occurring flavonoids. Flavonoids are known antioxidants that possess radioprotective properties. In order to investigate the radioprotective properties of novel glucosyl flavonoids, in vitro DNA double-strand breaks (DSBs) analysis was carried out. In the present study, Quercetin, Naringenin, and Hesperetin groups of flavonoids included in the natural and novel glucosyl 13 flavonoids were investigated. Flavonoids were mixed with Lambda DNA, and subsequently exposed to gamma‑rays. Furthermore, DNA DSB yields were visualized by gel electrophoresis. Quercetin derivatives displayed reduced DNA DSB formation at 10 µM. At a high concentration, the majority of flavonoids displayed radioprotective properties as a reduction of DSB yields. Suppression of DSB formation was confirmed via the molecular combing assay for Quercetin, and three monoglucosyl flavonoids. Glucosylation showed positive effects for radioprotection and monoglucosyl-Rutin showed superior radioprotective properties when compared to monoglucosyl-Naringin and Hesperidin. In addition, Quercetin derivatives had greater total antioxidant capacities and DPPH radical scavenging ability than other flavonoid groups. Since Quercetin, Isoquercetin, and Rutin display poor water solubility, monoglucosyl-Rutin, maltooligosyl-Isoquercetin, and maltooligosyl-Rutin may be better radioprotective agents and easily bioavailable with increased water solubility.},
 pages = {1525--1530},
 title = {In vitro screening of radioprotective properties in the novel glucosylated flavonoids.},
 volume = {38},
 year = {2016}
}