@article{oai:repo.qst.go.jp:00048225,
 author = {A Wells, J and L Thomas, D and Saga, T and Kershaw, J and Aoki, I and Saga, Tsuneo and Kershaw, Jeffrey and Aoki, Ichio},
 issue = {6},
 journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
 month = {Jan},
 note = {The study and clinical assessment of brain disease is currently hindered by a lack of non-invasive methods for the detailed and accurate evaluation of cerebral vascular pathology. Angiography can detect aberrant flow in larger feeding arteries/arterioles but cannot resolve the micro-vascular network. Small vessels are a key site of vascular pathology that can lead to haemorrhage and infarction, which may in turn trigger or exacerbate neurodegenerative processes. In this study, we describe a method to investigate microvascular flow anisotropy using a hybrid arterial spin labelling and multi-direction diffusion-weighted MRI sequence. We present evidence that the technique is sensitive to the mean/predominant direction of microvascular flow in localised regions of the rat cortex. The data provide proof of principle for a novel and non-invasive imaging tool to investigate cerebral micro-vascular flow patterns in healthy and disease states.},
 pages = {2076--2083},
 title = {MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach.},
 volume = {37},
 year = {2016}
}